Corticofugal projections from the anterior olfactory nucleus target olfactory bulb principal cells

The anterior olfactory nucleus (AON) is a cortical structure reciprocally connected with the olfactory bulb (OB) and the piriform cortex. Here, using small extracellular and intracellular injections to trace the terminal projections in the OB from individual cells in the rat AON, and examining the morphology and distribution of these projections, I report that these projections appear to preferentially target and directly synapses with mitral cells. These findings suggests that the AON acts to modulate incoming olfactory information based on ongoing processing, perhaps in a way that tunes the OB to signal the presence of particular odors