Improved health-related quality of life outcomes associated with SHH subgroup medulloblastoma in SIOP-UKCCSG PNET3 trial survivors

[Preview] Reduced health-related quality of life (HrQoL), including impaired cognitive, social, physical, behavioural and emotional functioning, is common in children treated for medulloblastoma and has been associated with clinical factors such as surgical resection and treatment modality]. recent biological advances have allowed the distinction of medulloblastomas into four consensus molecular subgroups—WNT, sHH, Group 3 and Group 4—which display distinct molecular, clinical, and pathological disease characteristics. Together, these observations raise the hypothesis that HrQoL in medulloblastoma survivors may be related to their underlying tumour biology