Aim: This paper discusses the critical determinants of pressure ulcer development and proposes a new pressure ulcer conceptual framework.Background: Recent work to develop and validate a new evidence-based pressure ulcer risk assessment framework was undertaken. This formed part of a Pressure UlceR Programme Of reSEarch (RP-PG-0407-10056), funded by the National Institute for Health Research. The foundation for the risk assessment component incorporated a systematic review and a consensus study that highlighted the need to propose a new conceptual framework.Design: Discussion Paper.Data Sources: The new conceptual framework links evidence from biomechanical, physiological and epidemiological evidence, through use of data from a systematic r...