Recent changes of the thermohaline circulation in the Eastern Mediterranean (i.e. the Eastern Mediterranean Transient) and older observations of the thermohaline structure of the Aegean-Levantine region (with events of dramatic changes of deep water characteristics) reveal the very sensitive character of the regional thermohaline circulation pattern. This and the long term variability of seawater characteristics in various Mediterranean basins show that the deep water mass formation processes in the region can be greatly affected by climate variability and the characteristics of the extreme atmospheric forcing events. Theoretical work and modeling experiments point out the effectiveness of extreme events and periods of abnormal atmospheric ...