Synthetic studies towards the core structure of nakadomarin A by a thioamide-based strategy

Chavda, Jai K.
Procopiou, Panayiotis A.
Horton, Peter N.
Coles, Simon J.
Porter, Michael J.

Publication date

January 2014

DOI

10.1002/ejoc.201301063

Publisher

Wiley

Abstract

The tricyclic BCD substructure of the marine natural product nakadomarin A has been synthesised. The strategy utilised a key carbon-carbon bond-forming reaction between a furan and an N-acyliminium ion derived from a secondary thiolactam. In addition, a novel three-component coupling reaction between a thioamide, an allylic bromide and an isocyanate, leading to the establishment of two new stereogenic centres, is reported.<br/

Extracted data

We use cookies to provide a better user experience.

Data Protection

Synthetic studies towards the core structure of nakadomarin A by a thioamide-based strategy

Abstract

Extracted data

Synthetic studies towards the core structure of nakadomarin A by a thioamide-based strategy

Abstract

Extracted data

Related items

Related items