Design and synthesis of a fluorescent molecular imprinted polymer for use in an optical fibre-based cocaine sensor

Previously, we have developed chemical sensors using fibre optic-based techniques for the detection of Cocaine, utilising molecularly imprinted polymers (MIPs) containing fluorescein moieties as the signalling groups. Here, we report the computational design of a fluorophore which was incorporated into a MIP for the generation of a novel sensor that offers improved sensitivity for Cocaine with a detection range of 1-100 micro-grams. High selectivity for Cocaine over a suite of known Cocaine interferants (25 micro-grams) was also demonstrated by measuring changes in the intensity of fluorescence signals received from the sensor