Glutathione S-transferases (GSTs) are a major family of detoxification enzymes which possess a wide range of substrate specificities. Most organisms possess many GSTs belonging to multiple classes. Interest in GSTs in insects is focused on their role in insecticide resistance; many resistant insects have elevated levels of GST activity. In the malaria vector Anopheles gambiae, elevated GST levels are associated with resistance to the organochlorine insecticide DDT [1,1,1-trichloro-2,2-bis-(p-chlorophenyl)ethane]. This mosquito is the source of an insect GST, agGSTd1-6, which metabolizes DDT and is inhibited by a number of pyrethroid insecticides. The crystal structure of agGSTd1-6 in complex with its inhibitor S-hexyl glutathione has been d...
The development of resistance to insecticides has become a classic exemplar of evolution occurring w...
A new study integrates biochemistry, genetics and structural biology to reveal the mechanism of meta...
<div><p>The development of resistance to insecticides has become a classic exemplar of evolution occ...
Mosquito glutathione S-transferases (GSTs) have received considerable attention in the last 20 years...
The glutathione S-transferases (GST) genes are a multigene family of enzymes involved in the metabol...
Background & objectives: Interest in insect glutathione s-transferases (GSTs) has primarily focused ...
The insect GST (glutathione transferase) supergene family encodes a varied group of proteins belongi...
The glutathione transferases (glutathione S-transferases, GSTs) are a diverse family of enzymes invo...
AbstractGlutathione S-transferases are important detoxification enzymes involved in insecticide resi...
In this report, we describe the glutathione transferase (GST) gene family in the dengue vector Aedes...
The development of resistance to insecticides has become a classic exemplar of evolution occurring w...
Glutathione transferases are multifunctional enzymes. Some of the known functions of the enzymes are...
GSTD1 is one of several insect glutathione S-transferases capable of metabolizing the insecticide DD...
As classical phase II detoxification enzymes, glutathione S-transferases (GSTs) have been implicated...
The Epsilon glutathione transferase (GST) class in the dengue vector Aedes aegypti consists of eight...
The development of resistance to insecticides has become a classic exemplar of evolution occurring w...
A new study integrates biochemistry, genetics and structural biology to reveal the mechanism of meta...
<div><p>The development of resistance to insecticides has become a classic exemplar of evolution occ...
Mosquito glutathione S-transferases (GSTs) have received considerable attention in the last 20 years...
The glutathione S-transferases (GST) genes are a multigene family of enzymes involved in the metabol...
Background & objectives: Interest in insect glutathione s-transferases (GSTs) has primarily focused ...
The insect GST (glutathione transferase) supergene family encodes a varied group of proteins belongi...
The glutathione transferases (glutathione S-transferases, GSTs) are a diverse family of enzymes invo...
AbstractGlutathione S-transferases are important detoxification enzymes involved in insecticide resi...
In this report, we describe the glutathione transferase (GST) gene family in the dengue vector Aedes...
The development of resistance to insecticides has become a classic exemplar of evolution occurring w...
Glutathione transferases are multifunctional enzymes. Some of the known functions of the enzymes are...
GSTD1 is one of several insect glutathione S-transferases capable of metabolizing the insecticide DD...
As classical phase II detoxification enzymes, glutathione S-transferases (GSTs) have been implicated...
The Epsilon glutathione transferase (GST) class in the dengue vector Aedes aegypti consists of eight...
The development of resistance to insecticides has become a classic exemplar of evolution occurring w...
A new study integrates biochemistry, genetics and structural biology to reveal the mechanism of meta...
<div><p>The development of resistance to insecticides has become a classic exemplar of evolution occ...