Do reactive oxygen species regulate skeletal muscle glucose uptake during contraction?

This review examines the evidence for ROS as signaling intermediates in the regulation of skeletal muscle glucose uptake during contraction. It is important to highlight that the pathway through which contraction regulates skeletal muscle glucose uptake differs from that of insulin-stimulated glucose uptake (20) and that ROS, in particular H2O2, also are implicated in the regulation of insulin-stimulated glucose uptake (33)