Famosa: Evaluation of a multigene panel in patients with suspected HBOC
- Adrover, E.
- Esteban, I.
- Llort, G.
- Servitja, S.
- Peralta, S.M.
- Garau, I.
- Cano, J.M.
- Serrano, R.
- Fita, M.J.J.
- Casas, A.
- Grana, B.
- Teule, A.
- Marquez, A.
- Martinez, J.E.A.
- Antón, A.
- Brunet, J.
- Balaguer, F.
- Gonzalez, S.
- Balmana, J.
- Alonso, C.
DOIAbstract
Background: Objectives: Characterize 1) the frequency of mutations in patients with clinical criteria for HBOC using a 25-gene panel in a Spanish population (FAMOSA study). 2) The psychological impact of these tests and patient''s counseling preferences. Methods: Patients with breast or ovarian cancer who met the NCCN criteria for genetic testing with a) prior testing for BRCA genes with NO mutation identified; or b) recently diagnosed (<6 months) and not genetically tested, were enrolled for multiplex cancer testing (MyRisk 25-gene panel). Participants completed self-questionnaires regarding geneting counseling preferences and three psychological scales (MICRA, CWS, R-IES) at base-line, one week, three and twelve months after results discl...
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