Recent Advances on Asymmetric Nitroso Aldol Reaction

The reaction of aromatic nitroso derivatives with enolizable carbonyl compounds (nitroso aldol reaction) to give either a-hydroxyamino or a-aminoxy carbonyl compounds is an important synthetic method. This review illustrates the recent advances in rendering the process regio- and enantioselective as well as catalytic. By employing metal and organic catalysts a range of a-amino (a-oxyamination) and a-hydroxy (a-aminoxylation) carbonyl derivatives can be generated with total regioselectivity and high levels of enantiomeric excess