STUDY OF MOLECULAR DOCKING OF ANTIHIPERGLICEMIC COMPOUNDS ON KELOR (Moringa oleifera) ON RECEPTOR PPAR-γ AS THERAPY FOR TYPE 2 DIABETES MELLITUS

Diabetes mellitus (DM) is a degenerative disease caused either when the pancreas can not produce enoughinsulin or when the body can not use effectively produced insulin. Kelor (Moringa oleifera) has been widelyused by the community as a food ingredient as well as the prevention and treatment of diabetes. In the leavescontain compounds that can act as antihiperglikemik drug. One of the receptors that play a role in the treatmentof diabetes is Peroxisome Proliferator-Activator Receptor-Gamma (PPAR-γ). The in silico method has beendeveloped and widely used in developing pharmacological hypotheses and testing. This study aims to determinethe interaction between PPAR-γ and Moringa oleifera compounds. In this study, the interactions between thecompounds in the Kelor leaf as ligand, with PPAR-γ observed using PyRx software, which is a program that cantether the ligand molecule to the receptor macromolecule. Then visualized using Pymol and PLIP. The resultsshow that the compounds exhibit a bond energy bond range between -8.0 to -4.7. Among the three compounds isknown that Quercetin has the greatest potential as antihyperglycemic seen from the bond energy value is -8,0,the number of hydrogen bonds are as much as 3, the shortest distance of the bonds is 1,94 and RMSD is 1,372.In this study also expected to find new drugs for the treatment of type 2 diabetes mellitu