Pyrrolo[3,2-c]pyridine derivatives as inhibitors of platelet aggregation

Altomare C.
Summo L.
Cellamare S.
Varlamov A.V.
Voskressensky L.G.
Borisova T.N.
Carotti A.

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Publication date

March 2020

DOI

10.1016/S0960-894X(00)00052-4

Publisher

Elsevier BV

Abstract

A series of pyrrolo[3,2-c]pyridines, isosteres of the antithrombotic drug ticlopidine, has been synthesized and evaluated in vitro for the ability to inhibit aggregation of human platelet-rich plasma induced by adenosin 5'-diphosphate (ADP). Structure-activity relationships showed their antiplatelet effects to be related to the Lipophilicity. (C) 2000 Elsevier Science Ltd. All rights reserved

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Pyrrolo[3,2-c]pyridine derivatives as inhibitors of platelet aggregation

Abstract

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Pyrrolo[3,2-c]pyridine derivatives as inhibitors of platelet aggregation

Abstract

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