Pharmacological regulation with antioxidants of hepatocyte cytolysis in acute D-galactosamine-induced intoxication

A rat model of D-galactosamine-induced (0.3 g/kg) liver damage is used to study antioxidant and membrane-stabilizing activity of sodium selenite, vitamin E, and their combination (administered per os, daily, for 3 days before intoxication). It is shown that sodium selenite is 300-fold more effective than vitamin E, while their combination exhibits synergism and potentiation of the antioxidant and membrane-stabilizing activities, underlying inhibition of hepatocyte cytolysis. ©1998 Plenum Publishing Corporation