Tris(2,6-dimethoxyphenyl)methyl carbenium ion as a charge derivatization agent for the analysis of primary amines by MALDI mass spectrometry
- Topolyan A.P.
- Strizhevskaya D.A.
- Slyundina M.S.
- Belyaeva M.A.
- Ivanova O.M.
- Korshun V.A.
- Ustinov A.V.
- Mikhura I.V.
- Formanovsky A.A.
- Borisov R.S.
DOIAbstract
A novel derivatization method for the analysis of primary amines by MALDI mass spectrometry is proposed. Tris(2,6-dimethoxyphenyl) methyl carbenium cation reacts smoothly with primary amines, forming permanently charged adducts with the mass increment +359 Da and absorbance in the UV region. The approach was tested on a number of amines, including biologically active compounds and therapeutic agents. © 2016, Pleiades Publishing, Ltd
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