Background: Exosomes, small extracellular vesicles of endosomal origin, have been suggested to be involved in both the metabolism and aggregation of Alzheimer’s disease (AD)-associated amyloid β-protein (Aβ). Despite their ubiquitous presence and the inclusion of components which can potentially interact with Aβ, the role of exosomes in regulating synaptic dysfunction induced by Aβ has not been explored. Results: We here provide in vivo evidence that exosomes derived from N2a cells or human cerebrospinal fluid can abrogate the synaptic-plasticity-disrupting activity of both synthetic and AD brain-derived Aβ. Mechanistically, this effect involves sequestration of synaptotoxic Aβ assemblies by exosomal surface proteins such as PrPC rather tha...
Evidence for a central role of amyloid β-protein (Aβ) in the genesis of Alzheimer’s disease (AD) has...
Exosomes are microvesicles secreted by many cells upon fusion of multivesicular endosomes with plasm...
BACKGROUND: It is becoming increasingly evident that deficits in the cortex and hippocampus at early...
Background: Exosomes, small extracellular vesicles of endosomal origin, have been suggested to be in...
AbstractElevated amyloid-β peptide (Aβ) in brain contributes to Alzheimer’s disease (AD) pathogenesi...
Summary The early stages of Alzheimer’s disease are associated with synaptic dysfunction prior to ov...
Amyloid-β (Aβ) associates with extracellular vesicles termed exosomes. It is not clear whether and h...
Synapse loss is an early and invariant feature of Alzheimer's disease (AD) and there is a strong cor...
Alzheimer’s disease (AD) is the most common neurodegenerative disease. It is known to be a multifact...
Extracellular vesicles (EVs), like exosomes, play a critical role in physiological processes, includ...
The early stages of Alzheimer's disease are associated with synaptic dysfunction prior to overt loss...
Exosomes are small membranous vesicles secreted by a number of cell types including neurons and can ...
Extracellular exosomes are formed inside the cytoplasm of cells in compartments known as multivesicu...
Alzheimer’s disease (AD) is the most common type of dementia affecting regions of the central nervou...
Alzheimer's disease (AD) is considered by many to be a synaptic failure. Synaptic function is in fac...
Evidence for a central role of amyloid β-protein (Aβ) in the genesis of Alzheimer’s disease (AD) has...
Exosomes are microvesicles secreted by many cells upon fusion of multivesicular endosomes with plasm...
BACKGROUND: It is becoming increasingly evident that deficits in the cortex and hippocampus at early...
Background: Exosomes, small extracellular vesicles of endosomal origin, have been suggested to be in...
AbstractElevated amyloid-β peptide (Aβ) in brain contributes to Alzheimer’s disease (AD) pathogenesi...
Summary The early stages of Alzheimer’s disease are associated with synaptic dysfunction prior to ov...
Amyloid-β (Aβ) associates with extracellular vesicles termed exosomes. It is not clear whether and h...
Synapse loss is an early and invariant feature of Alzheimer's disease (AD) and there is a strong cor...
Alzheimer’s disease (AD) is the most common neurodegenerative disease. It is known to be a multifact...
Extracellular vesicles (EVs), like exosomes, play a critical role in physiological processes, includ...
The early stages of Alzheimer's disease are associated with synaptic dysfunction prior to overt loss...
Exosomes are small membranous vesicles secreted by a number of cell types including neurons and can ...
Extracellular exosomes are formed inside the cytoplasm of cells in compartments known as multivesicu...
Alzheimer’s disease (AD) is the most common type of dementia affecting regions of the central nervou...
Alzheimer's disease (AD) is considered by many to be a synaptic failure. Synaptic function is in fac...
Evidence for a central role of amyloid β-protein (Aβ) in the genesis of Alzheimer’s disease (AD) has...
Exosomes are microvesicles secreted by many cells upon fusion of multivesicular endosomes with plasm...
BACKGROUND: It is becoming increasingly evident that deficits in the cortex and hippocampus at early...