Add to ORKG© 2019 by the authors. Licensee MDPI, Basel, Switzerland. The development of multicistronic vectors has opened up new opportunities to address the fundamental issues of molecular and cellular biology related to the need for the simultaneous delivery and joint expression of several genes. To date, the examples of the successful use of multicistronic vectors have been described for the development of new methods of treatment of various human diseases, including cardiovascular, oncological, metabolic, autoimmune, and neurodegenerative disorders. The safety and effectiveness of the joint delivery of therapeutic genes in multicistronic vectors based on the internal ribosome entry site (IRES) and self-cleaving 2A peptides have been shown in both ...
Gene therapy can be defined as the introduction of exogenous nucleic acids into cells with the inte...
Background: Transgenic animals are widely used in biomedical research and biotechnology. Multicistr...
Mouse artificial chromosome (MAC) vectors have several advantages as gene delivery vectors, such as ...
© 2019 by the authors. Licensee MDPI, Basel, Switzerland. The development of multicistronic vectors ...
The development of multicistronic vectors has opened up new opportunities to address the fundamental...
Gene discovery and gene therapy call for advanced technologies to reliably assess gene expression; e...
Internal ribosome entry site (IRES) sequences have become a valuable tool in the construction of gen...
When expression of more than one gene is required in cells, bicistronic or multicistronic expression...
Gene therapy, which aims to cure diseases by knocking out, editing, correcting or compensating abnor...
www.tcrt.org Gene therapy as part of modern molecular medicine holds great promise for the treatment...
Plasmid DNAs isolated from lactic acid bacteria (LAB) such as Lactococcus lactis (L. lactis) has bee...
Cloning of multiple genes in a single vector has greatly facilitated both basic and translational st...
Applications of viral vectors have found an encouraging new beginning in gene therapy in recent year...
Abstract: Several viruses have been engineered for gene therapy applications, and the specific prope...
In order to co-express multiple genes for biotechnological and biomedical applications, several appr...
Gene therapy can be defined as the introduction of exogenous nucleic acids into cells with the inte...
Background: Transgenic animals are widely used in biomedical research and biotechnology. Multicistr...
Mouse artificial chromosome (MAC) vectors have several advantages as gene delivery vectors, such as ...
© 2019 by the authors. Licensee MDPI, Basel, Switzerland. The development of multicistronic vectors ...
The development of multicistronic vectors has opened up new opportunities to address the fundamental...
Gene discovery and gene therapy call for advanced technologies to reliably assess gene expression; e...
Internal ribosome entry site (IRES) sequences have become a valuable tool in the construction of gen...
When expression of more than one gene is required in cells, bicistronic or multicistronic expression...
Gene therapy, which aims to cure diseases by knocking out, editing, correcting or compensating abnor...
www.tcrt.org Gene therapy as part of modern molecular medicine holds great promise for the treatment...
Plasmid DNAs isolated from lactic acid bacteria (LAB) such as Lactococcus lactis (L. lactis) has bee...
Cloning of multiple genes in a single vector has greatly facilitated both basic and translational st...
Applications of viral vectors have found an encouraging new beginning in gene therapy in recent year...
Abstract: Several viruses have been engineered for gene therapy applications, and the specific prope...
In order to co-express multiple genes for biotechnological and biomedical applications, several appr...
Gene therapy can be defined as the introduction of exogenous nucleic acids into cells with the inte...
Background: Transgenic animals are widely used in biomedical research and biotechnology. Multicistr...
Mouse artificial chromosome (MAC) vectors have several advantages as gene delivery vectors, such as ...