Efficiency of electrochemical amination of anisole in aqueous-organic solutions of 4 M H 2SO 4

Cathodically initiated amination of anisole has been performed with the Ti(IV)-NH 2OH system in aqueous solutions of 4 M H2SO4 containing high concentration of acetic acid or acetonitrile. In electrolyses performed to reach full conversion of hydroxylamine, the isomeric anisidines obtained (2 para/ortho ∼ 3.9) with total yields referred to the current and amino radical source exceeded 80%. © Pleiades Publishing, Ltd., 2012