We analyze inelastic off-fault response during earthquakes. Spontaneous crack-like rupture, with slip weakening, is modeled in 2-D plane strain using an explicit dynamic finite element procedure. A Mohr-Coulomb type elastic-plastic description describes the material bordering the fault. We identify the factors which control the extent and distribution of off-fault plasticity during dynamic rupture. Those include the angle with the fault of the maximum compressive prestress, the seismic S ratio, and the closeness of the initial stress state to Mohr-Coulomb failure. Plastic response can significantly alter the rupture propagation velocity, delaying or even preventing a transition to supershear rupture in some cases. Plastic straining also alt...