Previous Studies have suggested decreased N-methyl-D-aspartate (NMDA)-type glutamate receptor function may contribute to increased negative symptoms in patients with schizophrenia. Consistent with this hypothesis, glycine, a co-agonist at NMDA receptors, has been reported to improve negative symptoms associated with the illness. This study was performed to determine if plasma levels of glycine or its ratio to serine, a precursor of glycine, are decreased in patients with schizophrenia compared to normal control subjects or patients with major depression. We also tested the hypothesis that these amino acids were correlated with negative symptoms in subjects with schizophrenia. Plasma levels of glycine, serine, and their ratio, were compared ...
Treatment-resistant schizophrenia (TRS) or suboptimal response to antipsychotics affects almost 30% ...
Reduced activity of the N-methyl-D-aspartate receptor (NMDAR) has been implicated in the pathophysio...
The glutamate hypothesis of schizophrenia, proposed over two decades ago, originated following the o...
Glycine increases N-methyl-d-aspartate receptor (NMDAR) mediated glutamatergic function. Mismatch ne...
Schizophrenia is commonly associated with impairments in pre-attentive change detection as represent...
Schizophrenia is associated with impairments in pre-attentive change detection, as represented by re...
An impaired capacity to filter or ‘gate’ sensory information is a core deficit in cognitive function...
Schizophrenia is a severe chronic psychiatric illness, characterized by hallucinations and delusions...
The potential implication of a decrease in the function of N-methyl-D-aspartate receptors (NMDARs) i...
The potential implication of a decrease in the function of N-methyl-d-aspartate receptors (NMDARs) i...
The NMDA receptor co-agonists D-serine and glycine are thought to contribute to glutamatergic dysfun...
Schizophrenia is a severe mental illness that affects ~1% of the world's population. It is clinicall...
Schizophrenia is associated with impairments in pre-attentive change detection, as represented by re...
Background: Recent research attempting to develop novel medications has turned to glutamatergic sign...
Glycine is a noncompetitive co-agonist of NMDA receptor, ionotropic receptor of glutamatergic brain ...
Treatment-resistant schizophrenia (TRS) or suboptimal response to antipsychotics affects almost 30% ...
Reduced activity of the N-methyl-D-aspartate receptor (NMDAR) has been implicated in the pathophysio...
The glutamate hypothesis of schizophrenia, proposed over two decades ago, originated following the o...
Glycine increases N-methyl-d-aspartate receptor (NMDAR) mediated glutamatergic function. Mismatch ne...
Schizophrenia is commonly associated with impairments in pre-attentive change detection as represent...
Schizophrenia is associated with impairments in pre-attentive change detection, as represented by re...
An impaired capacity to filter or ‘gate’ sensory information is a core deficit in cognitive function...
Schizophrenia is a severe chronic psychiatric illness, characterized by hallucinations and delusions...
The potential implication of a decrease in the function of N-methyl-D-aspartate receptors (NMDARs) i...
The potential implication of a decrease in the function of N-methyl-d-aspartate receptors (NMDARs) i...
The NMDA receptor co-agonists D-serine and glycine are thought to contribute to glutamatergic dysfun...
Schizophrenia is a severe mental illness that affects ~1% of the world's population. It is clinicall...
Schizophrenia is associated with impairments in pre-attentive change detection, as represented by re...
Background: Recent research attempting to develop novel medications has turned to glutamatergic sign...
Glycine is a noncompetitive co-agonist of NMDA receptor, ionotropic receptor of glutamatergic brain ...
Treatment-resistant schizophrenia (TRS) or suboptimal response to antipsychotics affects almost 30% ...
Reduced activity of the N-methyl-D-aspartate receptor (NMDAR) has been implicated in the pathophysio...
The glutamate hypothesis of schizophrenia, proposed over two decades ago, originated following the o...