Early Renal Dysfunction in Obese Patients with Insulin Resistance

Background and aims: Obese individuals have insulin resistance status assessed in the present study by the HOMA index ("Homeostasis model assessment"). This prospective study assessed renal disorders in the insulin resistance in obese patients. Material and Methods: The study included 73 young obese patients. The assessment included the HOMA index before meal and parameters of renal function (glomerular filtration rate, albuminuria, β2-microglobulinuria). Results: In young obese, insulin-resistance patients, glomerular hyperfiltration and β2-microglobulinuria are found in 77.0 and 93.4% of cases respectively. The albuminuria is noted in some cases, which reduces diagnostic value. Conclusions: In young obese patients with insulin resistance, glomerular hyperfiltration and β2-microglobulinuria are main diagnostic markers of renal dysfunction