Effect of Clotrimazole-Satureja Bachtiarica Vaginal Cream and Clotrimazole Vaginal Cream in Patients with Vaginal Candidiasis

Abstract: Introduction Recently, there have been some reports about the antifungal and antimicrobial effects of Satureja bachtiarica. This study aimed to determine the effects of Clotrimazole-Satureja bachtiarica vaginal cream and compare with those of Clotrimazole vaginal cream in patients with vaginal candidiasis. Methods This randomized double-blind clinical trial was carried out on 80 women of childbearing age that referred to Hajar Hospital in Shahrekord, Iran. The cases in the first group received Clotrimazole-Satureja bachtiarica vaginal cream and in the second group, the patients received Clotrimazole vaginal cream. Clinical and laboratory signs and symptoms were recorded at baseline and after the treatment by questionnaires and forms. Both groups were treated for 7 days. The data were analyzed in SPSS software (version 21) using paired t-test, Chi-square test, repeated measures, and independent t-test. P-value less than 0.05 was considered statistically significant. Results The results of the present study showed that the amount of vaginal discharge (P=0.0001), dysuria (P=0.014), and vaginal itching (P=0.048) in the Clotrimazole-Satureja group were significantly less than those of the Clotrimazole group. There was no significant differences in the erythema of the vulva and vagina (P=0.108), as well as dyspareunia (P=0.118), between the Clotrimazole-Satureja group and the Clotrimazole group. No significant correlation was observed between the recarturrent and the studied groups (P=0.130). Conclusion The results of this study showed that the therapeutic effects of Clotrimazole-Satureja bachtiarica vaginal cream were not only similar to those of Clotrimazole vaginal cream but also more effective at improving the symptoms of vaginal candidiasis. Therefore, the use of this cream is suggested for the treatment of vaginal candidiasis infection Keywords:candidiasis , clotrimazole , Satureja , Vulvovaginiti