Add to ORKGA catalytic enantioselective approach to the Myrioneuron alkaloids (−)-myrifabral A and (−)-myrifabral B is described. The synthesis was enabled by a palladium-catalyzed enantioselective allylic alkylation, that generates the C(10) all-carbon quaternary center. A key N-acyl iminium ion cyclization forged the cyclohexane fused tricyclic core, while vinyl boronate cross metathesis and oxidation afforded the lactol ring of (−)-myrifabral A. Adaptation of previously reported conditions allowed for the conversion of (−)-myrifabral A to (−)-myrifabral B
The application of organocatalysis has expanded significantly in recent years. Organocatalysts can g...
The enantioselective synthesis of nitrogen-containing heterocycles (N-heterocycles) represents a sub...
Ir-catalyzed asymmetric alkene hydrogenation is presented as the strategy par excellence to prepare ...
A catalytic enantioselective approach to the Myrioneuron alkaloids (−)-myrifabral A and (−)-myrifabr...
The stereoselective total synthesis of myriocin was achieved by using the Du Bois Rh(II)-catalyzed C...
We describe the development of a strategy for the construction of the quaternary carbon stereocenter...
A strategy has been developed that culminated in a stereoselective total synthesis of the tetracycli...
A new protocol for the asymmetric synthesis of trans-2,6-disubstituted-4-piperidones has been develo...
A feasible and enantioselective total synthesis of (−)-trans-dihydronarciclasine [(−)-1], a highly b...
An enantioselective gram-scale synthesis of a key dihydroindolizine intermediate for the preparation...
Research in the Stoltz group aims, generally, to develop novel technologies for the preparation of s...
The authors would like to acknowledge EPSRC for PhD funding through the Doctoral Training Schemes.Th...
Pyrroloisoquinoline (n = 1) and the pyridoisoquinoline (n = 2) ring systems (2) are found to be the ...
The first total synthesis of the <i>Myrioneuron</i> alkaloids (±)-α,β-myrifabral A and B has been ac...
Pd-catalyzed enantioselective alkylation in conjunction with further synthetic elaboration enables t...
The application of organocatalysis has expanded significantly in recent years. Organocatalysts can g...
The enantioselective synthesis of nitrogen-containing heterocycles (N-heterocycles) represents a sub...
Ir-catalyzed asymmetric alkene hydrogenation is presented as the strategy par excellence to prepare ...
A catalytic enantioselective approach to the Myrioneuron alkaloids (−)-myrifabral A and (−)-myrifabr...
The stereoselective total synthesis of myriocin was achieved by using the Du Bois Rh(II)-catalyzed C...
We describe the development of a strategy for the construction of the quaternary carbon stereocenter...
A strategy has been developed that culminated in a stereoselective total synthesis of the tetracycli...
A new protocol for the asymmetric synthesis of trans-2,6-disubstituted-4-piperidones has been develo...
A feasible and enantioselective total synthesis of (−)-trans-dihydronarciclasine [(−)-1], a highly b...
An enantioselective gram-scale synthesis of a key dihydroindolizine intermediate for the preparation...
Research in the Stoltz group aims, generally, to develop novel technologies for the preparation of s...
The authors would like to acknowledge EPSRC for PhD funding through the Doctoral Training Schemes.Th...
Pyrroloisoquinoline (n = 1) and the pyridoisoquinoline (n = 2) ring systems (2) are found to be the ...
The first total synthesis of the <i>Myrioneuron</i> alkaloids (±)-α,β-myrifabral A and B has been ac...
Pd-catalyzed enantioselective alkylation in conjunction with further synthetic elaboration enables t...
The application of organocatalysis has expanded significantly in recent years. Organocatalysts can g...
The enantioselective synthesis of nitrogen-containing heterocycles (N-heterocycles) represents a sub...
Ir-catalyzed asymmetric alkene hydrogenation is presented as the strategy par excellence to prepare ...