\u3cp\u3eRadiotherapy aims at irradiating tumor tissue, while sparing normal tissue as much as possible and it is a suitable treatment option for prostate cancer. A crucial aspect of the radiotherapy workflow is patient positioning. It has been shown that frequent imaging during the course of the treatment (image guided radiotherapy) can improve this positioning accuracy. Despite the many advantages of ultrasound imaging (high soft tissue contrast, 4D imaging, etc.) its use in image guided radiotherapy workflows is not widespread. This can be primarily attributed to the need for a trained operator during image acquisition. In this study, patient-specific transperineal ultrasound probe setups were automatically calculated based on CT scans o...