Macrophage colony‐stimulating factor (CSF1 or M‐CSF) and interleukin 34 (IL34) are secreted cytokines that control macrophage survival and differentiation. Both act through the CSF1 receptor (CSF1R), a type III transmembrane receptor tyrosine kinase. The functions of CSF1R and both ligands are conserved in birds. We have analyzed protein‐coding sequence divergence among avian species. The intracellular tyrosine kinase domain of CSF1R was highly conserved in bird species as in mammals but the extracellular domain of avian CSF1R was more divergent in birds with multiple positively selected amino acids. Based upon crystal structures of the mammalian CSF1/IL34 receptor‐ligand interfaces and structure‐based alignments, we identified amino acids ...
<p>Tumor necrosis factor-α (TNF-α) is a pleiotropic cytokine playing critical roles in host defense ...
This dissertation explores the identity and role of immunoglobulin-like (Ig-like) receptors in chick...
<p>Tumor necrosis factor-α (TNF-α) is a pleiotropic cytokine playing critical roles in host defense ...
Macrophage colony-stimulating factor (CSF1 or M-CSF) and interleukin 34 (IL34) are secreted cytokine...
Macrophages, phagocytic cells of the immune system involved in host defence, homeostasis and develo...
Macrophages are involved in many aspects of develop-ment, host defense, pathology, and homeostasis. ...
CSF1R is the unique receptor ty-rosine kinase of CSF-1, whichregulates mononuclear phago-cyte and os...
Macrophages are involved in many aspects of development, host defense, pathology, and homeostasis. T...
Macrophages are present in every tissue, and have a central role in immune responses, development a...
Macrophages contribute to innate and acquired immunity as well as many aspects of homeostasis and de...
Targeted disruptions of the mouse genes for cytokines, cytokine receptors, or components of cytokine...
Macrophage colony-stimulating factor (CSF1) is an essential growth factor to control the proliferati...
AbstractMacrophage Colony Stimulating Factor (CSF-1) controls the survival, differentiation and prol...
Tumor necrosis factor-alpha (TNF-alpha) is a pleiotropic cytokine playing critical roles in host def...
<p>Tumor necrosis factor-α (TNF-α) is a pleiotropic cytokine playing critical roles in host defense ...
<p>Tumor necrosis factor-α (TNF-α) is a pleiotropic cytokine playing critical roles in host defense ...
This dissertation explores the identity and role of immunoglobulin-like (Ig-like) receptors in chick...
<p>Tumor necrosis factor-α (TNF-α) is a pleiotropic cytokine playing critical roles in host defense ...
Macrophage colony-stimulating factor (CSF1 or M-CSF) and interleukin 34 (IL34) are secreted cytokine...
Macrophages, phagocytic cells of the immune system involved in host defence, homeostasis and develo...
Macrophages are involved in many aspects of develop-ment, host defense, pathology, and homeostasis. ...
CSF1R is the unique receptor ty-rosine kinase of CSF-1, whichregulates mononuclear phago-cyte and os...
Macrophages are involved in many aspects of development, host defense, pathology, and homeostasis. T...
Macrophages are present in every tissue, and have a central role in immune responses, development a...
Macrophages contribute to innate and acquired immunity as well as many aspects of homeostasis and de...
Targeted disruptions of the mouse genes for cytokines, cytokine receptors, or components of cytokine...
Macrophage colony-stimulating factor (CSF1) is an essential growth factor to control the proliferati...
AbstractMacrophage Colony Stimulating Factor (CSF-1) controls the survival, differentiation and prol...
Tumor necrosis factor-alpha (TNF-alpha) is a pleiotropic cytokine playing critical roles in host def...
<p>Tumor necrosis factor-α (TNF-α) is a pleiotropic cytokine playing critical roles in host defense ...
<p>Tumor necrosis factor-α (TNF-α) is a pleiotropic cytokine playing critical roles in host defense ...
This dissertation explores the identity and role of immunoglobulin-like (Ig-like) receptors in chick...
<p>Tumor necrosis factor-α (TNF-α) is a pleiotropic cytokine playing critical roles in host defense ...