Антиоксидантная терапия как новый метод профилактики и лечения гематологической токсичности химиотерапии рака молочной железы

The aim of our work was to study the effectiveness of antioxidant therapy in prevention and treatment of leucopenia; to investigate the influence of deficit of prooxidant system as to the risk of hematological disorders development (agranulocytosis development; to ground the necessity of application of antioxidant therapy for prevention and treatment of hematological toxicity of chemotherapy.Materials and methods of research: retrospective study of medical documentation, biochemical analyzes, radiological examination. The control group included 110 persons, the group with studied preparation – 80 ones. All patients were women with spread breast cancer, who were treated by the standard chemotherapy schemes. The studied group received antioxidant Thiotriazoline during the treatment.Results. In patients of the studied group, who received thiotriazoline in preventive and therapeutic regimes, the frequency of occurrence of leucopenia is reliably lower than in the control group of patients. Patients with the low level of SH-groups (less than 1 mmol/g of protein) at the parallel activation of oxidative stress are the group of neutropenia risk on the background of BC chemotherapy and need the dynamic observation with individual selection of thiol donors and preparations with verified antioxidant effect. The decrease of effectiveness of antioxidant enzymes of glutathione links and displacement of thiol-disulfide balance to the decrease of content of restored indicate the reliable clinical necessity of personal application of medical preparations with glutathione-protective effect and antioxidant potential such as Thiotriasoline, which clinical approbation was realized in our workЦелями нашего исследования было изучение влияния прооксидантно-оксидантного равновесия на риск развития гематологических нарушения после проводимой цитотоксической терапии при раке молочной железы, исследовать эффективность и целесообразность применения антиоксидантной терапии с целью профилактики и коррекции лейкопении. Проведенное исследование маркеров оксидативного стресса и клинических результатов применения антиоксидантов указывает на клиническую и лабораторную эффективность исследуемого препарат