Технологія дієтичної добавки антиліполітичної дії на основі фенольних сполук і біополімерів гливи

A rapid increase in the number of people suffering from abnormal weight gain is observed worldwide. Scientists have discovered a causal relationship between obesity and a number of serious diseases. At present, the only means used for correcting body weight is orlistat, which is a semi-synthetic medicine of non-Ukrainian production and a remedy that is not devoid of side effects.Our aim was to develop a technology of obtaining a dietary supplement that would produce antylipolitic effect and be based on substances of vegetable origin: phenolic compounds of rapeseed and a biopolymer complex of oyster mushrooms.It has been determined that the inhibitory activity of phenolic compounds of rapeseed that are immobilized on the biopolymer matrix of oyster mushrooms depends on the conditions of obtaining the latter. The highest levels of antylipolitic activity were found in antylipolitic preparations derived from the biopolymer complex that had been obtained through treating the raw material with water, acid, and a 7 % solution of sodium hydroxide. The selected duration of contact with the alkaline agent is 90 min.Rational conditions have been established for immobilization of the inhibitor on the carrier: saturation of the matrix with a 0.17% solution of phenolic compounds of rapeseed (hydrological module 6) at a temperature of +20-25°C for 20 minutes. Samples with an immobilized inhibitor have been found to surpass the intact form according to such properties as pH stability, thermal stability, stability under conditions simulating the gastrointestinal tract, and stability in storage.We have developed a technology of obtaining a dietary supplement of antylipolitic effect. The dietary supplement contains 1% of phenolic compounds of rapeseed while the rest of the structure consists of a biopolymer complex of oyster mushrooms that includes glucan, chitin, melanins, and protein. It is characterized by high levels of antylipolitic, antioxidant and enterosorption activities; moreover, it is able to stimulate growth of lactobacteria and bifidobacteria as well as to respond to the normalized indicators of microbiological safety.Разработана технология получения диетической добавки антилиполитического действия. Ингибитор липазы – фенольные соединения рапса иммобилизированы на биополимерном комплексе вешенки обыкновенной. Показано, что иммобилизованная форма ингибитора по сравнению с интактной имеет более высокие физико-химические показатели, а также степень сохранения активности как в условиях желудочно-кишечного тракта, так и при хранении.Розроблено технологію отримання дієтичної добавки антиліполітичної дії. Інгібітор ліпази – фенольні сполуки ріпаку іммобілізовано на біополімерному комплексі гливи звичайної. Показано, що іммобілізована форма інгібітору у порівнянні з інтактною має кращі фізико-хімічні показники, а також ступінь збереження активності як в умовах шлунково-кишкового тракту, так і при зберіганні