Cold storage is a common procedure for liver preservation in a transplant setting. However, during cold ischemia, the liver suffers molecular alterations that can affect its performance. Also, deleterious mechanisms set forth in the storage phase are exacerbated during reperfusion. This study aimed to identify liver proteins associated with injury during cold storage and/or normothermic reperfusion using the isolated perfused rat liver model. Livers from male rats were subjected to either (1) cold storage for 24 h, (2) ex vivo normothermic reperfusion for 90 min or (3) cold storage for 24 h followed by ex vivo normothermic reperfusion for 90 min. Then, the livers were homogenized and proteins were extracted. Protein expression between each ...
AIM: To develop a simplified bioartificial liver (BAL) device prototype, suitable to use freshly and...
This work is licensed under the Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 U...
Ischemia-reperfusion injury (IRI) causes up to 10\% of early liver failures in humans and can lead t...
Knowledge of early molecular events occurring upon ischemia/reperfusion (I/R) during liver transplan...
Knowledge of early molecular events occurring upon ischemia/reperfusion (I/R) during liver transplan...
Aims: Machine perfusion at subnormothermic temperature (20°C), MP20, was developed by Vairetti et al...
Background: Ischemic cholangitis is the main cause of liver failure after transplantation and subnor...
BackgroundAlthough proteomics has been employed in the study of several models of liver injury, prot...
BACKGROUND & AIMS: Primary hepatocytes are of great importance for basic research as well as cell tr...
Abstract: Hypothermic machine perfusion (MP) of the liver has been reported to improve graft functio...
Matrix metalloproteinases (MMPs) have been implicated in the hepatic injury induced after cold ische...
Primary hepatocytes are of great importance for basic research as well as cell transplantation. Howe...
The aim of this work was to compare the effi- ciency of cold storage (CS) and hypothermic machine pe...
Successful cryopreservation of PCLS would allow the building of a tissue bank and reduce the use of ...
Chilling injury is one of the limiting steps for successful vitrification of cells, organs and tissu...
AIM: To develop a simplified bioartificial liver (BAL) device prototype, suitable to use freshly and...
This work is licensed under the Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 U...
Ischemia-reperfusion injury (IRI) causes up to 10\% of early liver failures in humans and can lead t...
Knowledge of early molecular events occurring upon ischemia/reperfusion (I/R) during liver transplan...
Knowledge of early molecular events occurring upon ischemia/reperfusion (I/R) during liver transplan...
Aims: Machine perfusion at subnormothermic temperature (20°C), MP20, was developed by Vairetti et al...
Background: Ischemic cholangitis is the main cause of liver failure after transplantation and subnor...
BackgroundAlthough proteomics has been employed in the study of several models of liver injury, prot...
BACKGROUND & AIMS: Primary hepatocytes are of great importance for basic research as well as cell tr...
Abstract: Hypothermic machine perfusion (MP) of the liver has been reported to improve graft functio...
Matrix metalloproteinases (MMPs) have been implicated in the hepatic injury induced after cold ische...
Primary hepatocytes are of great importance for basic research as well as cell transplantation. Howe...
The aim of this work was to compare the effi- ciency of cold storage (CS) and hypothermic machine pe...
Successful cryopreservation of PCLS would allow the building of a tissue bank and reduce the use of ...
Chilling injury is one of the limiting steps for successful vitrification of cells, organs and tissu...
AIM: To develop a simplified bioartificial liver (BAL) device prototype, suitable to use freshly and...
This work is licensed under the Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 U...
Ischemia-reperfusion injury (IRI) causes up to 10\% of early liver failures in humans and can lead t...