In vivo study of teratogenic and anticonvulsant effects of antiepileptics drugs in zebrafish embryo and larvae

Martinez, Carolina Soledad
Feas, Daniela Agustina
Siri, Macarena
Igartúa, Daniela
Chiaramoni, Nadia Silvia
Alonso, Silvia del Valle
Prieto, Maria Jimena

Open link

Publication date

March 2018

DOI

10.1016/j.ntt.2018.01.008

Publisher

Elsevier BV

Journal

Neurotoxicology and Teratology

Abstract

Epilepsy is a neurological disorder treated with antiepileptic drugs (AEDs). Since AEDs are administered in women in childbearing age, it is critical to study if drugs are capable of inducing developmental toxicity. Along the bibliography available, there is no research comparing teratogenicity and anticonvulsant effect within the same study. In the present study, we evaluated the teratogenic and anticonvulsant effects of six different AEDs: carbamazepine, levetiracetam, lamotrigine, phenobarbital, phenytoin and valproic acid. Zebrafish was the selected animal model because of its small size, rapid external development and similar neurophysiology to mammals. Zebrafish embryo and larvae were exposed to AEDs. Embryo development was monitored ...