Purpose: Neuroblastoma is a pediatric tumor of peripheral sympathoadrenal neuroblasts. The long-term event-free survival of children with high-risk neuroblastoma is still poor despite the improvements with current multimodality treatment protocols. Activated JAK/STAT3 pathway plays an important role in many human cancers, suggesting that targeting STAT3 is a promising strategy for treating high-risk neuroblastoma. Experimental Design: To evaluate the biologic consequences of specific targeting of STAT3 in neuroblastoma, we assessed the effect of tetracycline (Tet)-inducible STAT3 shRNA and the generation 2.5 antisense oligonucleotide AZD9150 which targets STAT3 in three representative neuroblastoma cell line models (AS, NGP, and IMR32). Res...
Purpose: TERT gene rearrangement with transcriptional super-enhancers leads to TERT overexpression a...
High-risk neuroblastoma (NB) often involves MYCN amplification as well as mutations in ALK. Currentl...
Over the last decade Anaplastic Lymphoma Kinase (ALK), a receptor tyrosine kinase (RTK) has been ide...
Purpose: Neuroblastoma is a pediatric cancer that continues to exact significant morbidity and morta...
Brain cancer is the leading cause of cancer-related death in pediatric patients, and medulloblastoma...
Purpose: Patients with neuroblastoma associated with MYCN oncogene amplification experience a very p...
Purpose: Neuroblastoma (NB) is an aggressive tumor of the developing peripheral nervous system that ...
Peripheral neuroblastic tumors (PNTs) represent a spectrum of tumors derived from the neural crest a...
Neuroblastoma is a childhood tumor of the sympathetic nervous system and the most common tumor form ...
Purpose: Neuroblastoma (NB) is one of the most common and deadly pediatric solid tumors. NB is chara...
BackgroundNeuroblastoma is the second most common extracranial cancer in children. Current therapies...
Neuroblastoma (NB) is the most common extracranial solid tumor in infants, arising from the developi...
Signal transducers and activators of transcription (STATs) comprise a family of cytoplasmic transcri...
Purpose: TERT gene rearrangement with transcriptional super-enhancers leads to TERT overexpression a...
Purpose: mutations in the PI3K pathway occur in 16% of patients with pancreatic neuroendocrine tumor...
Purpose: TERT gene rearrangement with transcriptional super-enhancers leads to TERT overexpression a...
High-risk neuroblastoma (NB) often involves MYCN amplification as well as mutations in ALK. Currentl...
Over the last decade Anaplastic Lymphoma Kinase (ALK), a receptor tyrosine kinase (RTK) has been ide...
Purpose: Neuroblastoma is a pediatric cancer that continues to exact significant morbidity and morta...
Brain cancer is the leading cause of cancer-related death in pediatric patients, and medulloblastoma...
Purpose: Patients with neuroblastoma associated with MYCN oncogene amplification experience a very p...
Purpose: Neuroblastoma (NB) is an aggressive tumor of the developing peripheral nervous system that ...
Peripheral neuroblastic tumors (PNTs) represent a spectrum of tumors derived from the neural crest a...
Neuroblastoma is a childhood tumor of the sympathetic nervous system and the most common tumor form ...
Purpose: Neuroblastoma (NB) is one of the most common and deadly pediatric solid tumors. NB is chara...
BackgroundNeuroblastoma is the second most common extracranial cancer in children. Current therapies...
Neuroblastoma (NB) is the most common extracranial solid tumor in infants, arising from the developi...
Signal transducers and activators of transcription (STATs) comprise a family of cytoplasmic transcri...
Purpose: TERT gene rearrangement with transcriptional super-enhancers leads to TERT overexpression a...
Purpose: mutations in the PI3K pathway occur in 16% of patients with pancreatic neuroendocrine tumor...
Purpose: TERT gene rearrangement with transcriptional super-enhancers leads to TERT overexpression a...
High-risk neuroblastoma (NB) often involves MYCN amplification as well as mutations in ALK. Currentl...
Over the last decade Anaplastic Lymphoma Kinase (ALK), a receptor tyrosine kinase (RTK) has been ide...