The large diffusion of multi-core machines has pushed the research in the field of Parallel Discrete Event Simulation (PDES) toward new programming paradigms, based on the exploitation of shared memory. On the opposite side, the advent of Cloud computing—and the possibility to group together many (low-cost) virtual machines to form a distributed memory cluster capable of hosting simulation applications—has raised the need to bridge shared memory programming and seamless distributed execution. In this article, we present the design of a distributed middleware that transparently allows a PDES application coded for shared memory systems to run on clusters of (Cloud) resources. Our middleware is based on a synchronization protocol called Event ...