The Interplay between CD27dull and CD27bright B Cells Ensures the Flexibility, Stability, and Resilience of Human B Cell Memory
- Grimsholm O.
- Piano Mortari E.
- Davydov A. N.
- Shugay M.
- Obraztsova A. S.
- Bocci C.
- Marasco E.
- Marcellini V.
- Aranburu A.
- Farroni C.
- Silvestris D. A.
- Cristofoletti C.
- Giorda E.
- Scarsella M.
- Cascioli S.
- Barresi S.
- Lougaris V.
- Plebani A.
- Cancrini C.
- Finocchi A.
- Moschese V.
- Valentini D.
- Vallone C.
- Signore F.
- de Vincentiis G.
- Zaffina S.
- Russo G.
- Gallo A.
- Locatelli F.
- Tozzi A. E.
- Tartaglia M.
- Chudakov D. M.
- Carsetti R.
DOIAbstract
Grimsholm et al. show that CD27dull and CD27bright represent sequential MBC developmental stages. T cell- and germinal center (GC)-independent CD27dull MBCs are the plastic source of strongly selected and GC-dependent CD27bright MBCs. CD27dull MBCs, able to expand and differentiate in response to change, ensure stability and flexibility of human B cell memory
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