Health services’ quality relies on patients’ participation in the design and delivery of care. Inter alia, self-efficacy and awareness are paramount to realize the full potential of health services’ co-production. This paper investigates the effects of health literacy – i.e. the ability to access, understand, process, and use health information – on individual self-efficacy perceptions and awareness. A random sample of 591 Italian patients was built. The Newest Vital Sign (NVS) screening tool was used to measure individual health literacy skills; moreover, a self-reporting survey was designed to assess: (1) self-efficacy perceptions; (2) awareness; and (3) health services’ use. A multivariate regression model was used to investigate the rel...