Recently, due to the increasing complexity and wider adoption of heterogeneous Large-Scale systems and System-of-Systems (SoSs), the management of requirements, properties, emergent behaviors, and risks of integrations by coupling existing components, is becoming more and more challenging. Modeling and Simulation (MS) methodologies and tools can be usefully exploited to address this complexity and support the design of SoSs, so as to allow specialists to perform a more detailed and targeted analysis before the SoSs integration phase. Significant benefits may derive from Distributed Simulation (DS) and the IEEE 1516-2010 - High Level Architecture (HLA), which represents a well-known and widely used DS standard. Unfortunately, the standard do...