Add to ORKGEarly infancy (< 1 year of age), massive tumor cell burden, and extremely poor prognosis are characteristic features of a particular subset of childhood acute leukemias (AL). In these cases, chromosome aberrations at the 11q23 band are the most frequently reported cytogenetic abnormalities. We have recently cloned a genetic locus named ALL-1, in which DNA breakpoints are clustered in leukemic patients with 11q23 aberrations. Analysis of the ALL-1 genomic configuration in DNA from 15 infants with AL showed specific ALL-1 rearrangements in 12 cases (80%), including 5 with normal karyotypes. These findings indicate that a consistent genetic defect underlies this particular leukemic subset
In this study we investigated the presence of structural lesions in the ALL-1, p53 and p16 (cyclin-d...
In childhood acute lymphoblastic leukaemia (ALL), cytogenetics plays an essential role in diagnosis ...
In this study we investigated the presence of structural lesions in the ALL-1, p53 and p16 (cyclin-d...
Early infancy (< 1 year of age), massive tumor cell burden, and extremely poor prognosis are charact...
Early infancy (< 1 year of age), massive tumor cell burden, and extremely poor prognosis are charact...
Acute lymphoblastic leukemia (ALL) in infants generally shows distinctive biologic features and has ...
The chromosome 11q23 band is a genetic region frequently involved in nonrandom karyotypic abnormalit...
The chromosome 11q23 band is a genetic region frequently involved in nonrandom karyotypic abnormalit...
We and others have recently reported a high frequency (70-80%) of ALL-1 (MLL, HRX, HTRX) gene rearra...
Non random chromosomal abnormalities are associated with specific subgroups of leukaemia. These abno...
BACKGROUND AND OBJECTIVE: The ALL1 gene, also referred to as MLL, HRX or Htrx1, is interrupted in th...
Translocations involving chromosome band 11q23, found in 5-10% of human acute leukemias, disrupt the...
We have analyzed genomic DNAs from a patient who developed acute myeloid leukemia 1 year after a mye...
In this study we investigated the presence of structural lesions in the ALL-1, p53 and p16 (cyclin-d...
In this study we investigated the presence of structural lesions in the ALL-1, p53 and p16 (cyclin-d...
In childhood acute lymphoblastic leukaemia (ALL), cytogenetics plays an essential role in diagnosis ...
In this study we investigated the presence of structural lesions in the ALL-1, p53 and p16 (cyclin-d...
Early infancy (< 1 year of age), massive tumor cell burden, and extremely poor prognosis are charact...
Early infancy (< 1 year of age), massive tumor cell burden, and extremely poor prognosis are charact...
Acute lymphoblastic leukemia (ALL) in infants generally shows distinctive biologic features and has ...
The chromosome 11q23 band is a genetic region frequently involved in nonrandom karyotypic abnormalit...
The chromosome 11q23 band is a genetic region frequently involved in nonrandom karyotypic abnormalit...
We and others have recently reported a high frequency (70-80%) of ALL-1 (MLL, HRX, HTRX) gene rearra...
Non random chromosomal abnormalities are associated with specific subgroups of leukaemia. These abno...
BACKGROUND AND OBJECTIVE: The ALL1 gene, also referred to as MLL, HRX or Htrx1, is interrupted in th...
Translocations involving chromosome band 11q23, found in 5-10% of human acute leukemias, disrupt the...
We have analyzed genomic DNAs from a patient who developed acute myeloid leukemia 1 year after a mye...
In this study we investigated the presence of structural lesions in the ALL-1, p53 and p16 (cyclin-d...
In this study we investigated the presence of structural lesions in the ALL-1, p53 and p16 (cyclin-d...
In childhood acute lymphoblastic leukaemia (ALL), cytogenetics plays an essential role in diagnosis ...
In this study we investigated the presence of structural lesions in the ALL-1, p53 and p16 (cyclin-d...