Dust re-suspension as a consequences of loss of vacuum accident (LOVA) or loss of coolant accident (LOCA) situations inside a nuclear fusion plant (ITER-like) is an important issue for the workers’ safety and for the security of the plant. The dust size expected inside tokamaks like ITER is of the order of microns (0.1–1000 μm). Analysis of the thermo fluid-dynamics and transport phenomena involved during an accidental pressurization transitory is necessary in order to set up and operated tokamaks with careful consideration of the potential risks. Computational fluid dynamics (CFD) study of LOVA scenario is a challenging task for today numerical methods and models because it involves 3D large vacuum volumes, multiphase flows ranging from hi...