FoxO1 regulates asymmetric dimethylarginine via downregulation of dimethylaminohydrolase 1 in human endothelial cells and subjects with atherosclerosis
- MENGHINI, ROSSELLA
- Casagrande, V
- CARDELLINI, MARINA
- BALLANTI, MARTA
- Davato, F
- Cardolini, I
- Stoehr, R
- FABRIZI, MARTA
- Morelli, M
- ANEMONA, LUCIA
- Bernges, I
- Schwedhelm, E
- IPPOLITI, ARNALDO
- MAURIELLO, ALESSANDRO
- Boger, Rh
- FEDERICI, MASSIMO
Publication date
January 2015
DOIAbstract
The O subfamily of forkhead (FoxO) 1 is a pivotal element in the regulation of endothelial activation. Compartmentalization and activity of FoxO1 is regulated by post translational modifications, but the implication in endothelial dysfunction and atherosclerosis remain controversial. Our aim was to identify FoxO1 related metabolic signatures in endothelial cells
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