The genotypic false positive rate determined by V3 population sequencing can predict the burden of HIV-1 CXCR4-using species detected by pyrosequencing
- SVICHER, VALENTINA
- SANTORO, MARIA
- ANDREONI, MASSIMO
- CECCHERINI SILBERSTEIN, FRANCESCA
- PERNO, CARLO FEDERICO
- Cento, V
- Rozera, G
- Abbate, I
- Armenia, D
- Fabeni, L
- Bruselles, A
- Latini, A
- Palamara, G
- Micheli, V
- Rizzardini, G
- Gori, C
- Forbici, F
- Ippolito, G
- Antinori, A
- Capobianchi, M
Publication date
January 2013
DOI Publisher
Public Library of Science (PLoS)Abstract
The false-positive rate (FPR) is a percentage-score provided by Geno2Pheno-algorithm indicating the likelihood that a V3-sequence is falsely predicted as CXCR4-using. We evaluated the correlation between FPR obtained by V3 population-sequencing and the burden of CXCR4-using variants detected by V3 ultra-deep sequencing (UDPS) and Enhanced-Sensitivity Trofile assay (ESTA)
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