Add to ORKGThe gene for one form of autosomal dominant spinal cerebellar ataxia (SCA1), is mapped by linkage to chromosome 6p, very close to the microsatellite locus D6S89. Eight large Italian kindreds segregating SCA1, as defined by very close linkage to D6S89, were genotyped with five microsatellite markers linked closely to D6S89, all mapping within a 6 cM interval on 6p. Multipoint linkage analysis and haplotypes from recombinants map SCA1 between two of these markers, D6S274 and D6S259, 5-6 cM apart. A single rare four marker haplotype within this interval shows linkage disequilibrium with the disease locus in southern Italy and is transmitted with SCA1 in five kindreds originating from this area
none12We describe a four-generation Italian family with a novel form of juvenile-onset, slowly progr...
The autosomal dominant cerebellar ataxias (ADCA) are clinically and genetically heterogeneous. To da...
The spinocerebellar ataxias (SCAs) are a heterogeneous group of neurodegenerative disorders characte...
The gene for one form of autosomal dominant spinal cerebellar ataxia (SCA1), is mapped by linkage to...
The gene for one form of autosomal dominant spinal cerebellar ataxia (SCA1), is mapped by linkage to...
Spinocerebellar ataxia type 1 (SCA1) is an autosomal dominant disorder which is genetically linked t...
Spinocerebellar ataxia type 1 (SCA1) is an autosomal dominant disorder which is genetically linked t...
We studied three large kindreds with the HLA-linked form of spinocerebellar ataxia (SCA1) in order ...
We studied three large kindreds with the HLA-linked form of spinocerebellar ataxia (SCA1) in order t...
We present a linkage study in a four-generation autosomal dominant cerebellar ataxia (ADCA) family o...
We present a linkage study in a four-generation autosomal dominant cerebellar ataxia (ADCA) family o...
Two large Italian pedigrees with HLA-linked spinocerebellar ataxia (SCA1) were typed for HLA-A, -B a...
Two large Italian pedigrees with HLA-linked spinocerebellar ataxia (SCA1) were typed for HLA-A, -B a...
none12We describe a four-generation Italian family with a novel form of juvenile-onset, slowly progr...
The autosomal dominant cerebellar ataxias (ADCA) are clinically and genetically heterogeneous. To da...
The spinocerebellar ataxias (SCAs) are a heterogeneous group of neurodegenerative disorders characte...
The gene for one form of autosomal dominant spinal cerebellar ataxia (SCA1), is mapped by linkage to...
The gene for one form of autosomal dominant spinal cerebellar ataxia (SCA1), is mapped by linkage to...
Spinocerebellar ataxia type 1 (SCA1) is an autosomal dominant disorder which is genetically linked t...
Spinocerebellar ataxia type 1 (SCA1) is an autosomal dominant disorder which is genetically linked t...
We studied three large kindreds with the HLA-linked form of spinocerebellar ataxia (SCA1) in order ...
We studied three large kindreds with the HLA-linked form of spinocerebellar ataxia (SCA1) in order t...
We present a linkage study in a four-generation autosomal dominant cerebellar ataxia (ADCA) family o...
We present a linkage study in a four-generation autosomal dominant cerebellar ataxia (ADCA) family o...
Two large Italian pedigrees with HLA-linked spinocerebellar ataxia (SCA1) were typed for HLA-A, -B a...
Two large Italian pedigrees with HLA-linked spinocerebellar ataxia (SCA1) were typed for HLA-A, -B a...
none12We describe a four-generation Italian family with a novel form of juvenile-onset, slowly progr...
The autosomal dominant cerebellar ataxias (ADCA) are clinically and genetically heterogeneous. To da...
The spinocerebellar ataxias (SCAs) are a heterogeneous group of neurodegenerative disorders characte...