Accelerated lipid-induced atherogenesis in galectin-3-deficient mice: role of lipoxidation via receptor-mediated mechanisms
- Iacobini, C
- Menini, S
- Ricci, C
- Scipioni, A
- Sansoni, V
- Cordone, S
- Taurino, M
- Serino, M
- Marano, G
- Pricci, F
- Pugliese, G.
- FEDERICI, MASSIMO
DOIAbstract
Modified lipoproteins, particularly oxidized LDLs, are believed to evoke an inflammatory response which participates in all stages of atherosclerosis. Disposal of these particles is mediated through receptors which may trigger proinflammatory signaling pathways leading to vascular injury. This study was aimed at assessing the role in atherogenesis of one of these receptors, galectin-3
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