Up-regulation of proliferating cell nuclear antigen (PCNA) is closely associated with high-risk human papillomavirus (HPV) and progression of cervical intraepithelial neoplasia (CIN), but does not predict disease outcome in cervical cancer
- Branca, M
- Ciotti, M
- Giorgi, C
- Santini, D
- Di Bonito, L
- Benedetto, A
- Bonifacio, D
- Di Bonito, P
- Paba, P
- Accardi, L
- Syrjänen, S
- Syrjänen, K.
- COSTA, STEFANO
- FAVALLI, CARTESIO
DOIAbstract
Proliferating cell nuclear antigen (PCNA) is essential for DNA replication of mammalian cells and their small DNA tumour viruses. The E7 oncoprotein of high-risk human papillomavirus (HPV) is known to activate PCNA, shown to be up-regulated in CIN and cervical cancer (CC), but still incompletely studied as an intermediate endpoint marker in this disease
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