Increased cytokine-mediated cytotoxic natural killer (NK) cell activity has recently been demonstrated in patients with senile dementia of the Alzheimer's type (SDAT). In the present study, we evaluated whether protein-kinase C (PKC), a main regulatory enzyme involved in the mechanism of exocytosis by NK cells, has a role in the cytotoxic response of NK cells (during IL-2 and IFN-beta exposure) from SDAT patients. Our data demonstrate the presence of an increased cytotoxic response by NK cells to IL-2 (mean increase +102%) and IFN-beta (mean increase +132%) in SDAT patients in comparison with healthy elderly subjects (+75% and +88% for IL-2 and IFN-beta, respectively). A smaller suppression of NK cytotoxicity after cortisol was also observe...
The phenotype and functional activity of circulating T and natural killer (NK) cells was investigat...
Brain aging is characterized by a progressive decline of the cognitive and memory functions. It is b...
Brain aging is characterized by a progressive decline of the cognitive and memory functions. It is b...
Alzheimer’s disease (AD) represents the most common cause of dementia in the elderly. AD is a neurod...
Patients with Alzheimer's disease (AD) are characterized by an altered sensitivity to cortisol-media...
: A link between neuroendocrine and immunological changes has been suggested in the pathophysiology ...
Alzheimer's dementia (AD) is a degenerative brain disorder characterized mainly by cholinergic failu...
Ischemic stroke and Alzheimer’s disease (AD), despite being distinct disease entities, share numerou...
The emerging domain of epigenetics in molecular medicine finds application for a variety of patient ...
AbstractAlzheimer's dementia (AD) is a degenerative brain disorder characterized mainly by cholinerg...
Alzheimer's disease (AD), a neurodegenerative disorder, is the most common form of dementia in the e...
Aging is the greatest risk factor for nearly all major chronic diseases, including cardiovascular di...
We attempted to determine whether changes in protein kinase C (PKC) activity in Alzheimer's disease ...
Recent studies suggest that cellular senescence plays a role in Alzheimer’s Disease (AD) pathogenesi...
It is well known that the double-stranded RNA-dependent Protein Kinase (PKR) is not only activated i...
The phenotype and functional activity of circulating T and natural killer (NK) cells was investigat...
Brain aging is characterized by a progressive decline of the cognitive and memory functions. It is b...
Brain aging is characterized by a progressive decline of the cognitive and memory functions. It is b...
Alzheimer’s disease (AD) represents the most common cause of dementia in the elderly. AD is a neurod...
Patients with Alzheimer's disease (AD) are characterized by an altered sensitivity to cortisol-media...
: A link between neuroendocrine and immunological changes has been suggested in the pathophysiology ...
Alzheimer's dementia (AD) is a degenerative brain disorder characterized mainly by cholinergic failu...
Ischemic stroke and Alzheimer’s disease (AD), despite being distinct disease entities, share numerou...
The emerging domain of epigenetics in molecular medicine finds application for a variety of patient ...
AbstractAlzheimer's dementia (AD) is a degenerative brain disorder characterized mainly by cholinerg...
Alzheimer's disease (AD), a neurodegenerative disorder, is the most common form of dementia in the e...
Aging is the greatest risk factor for nearly all major chronic diseases, including cardiovascular di...
We attempted to determine whether changes in protein kinase C (PKC) activity in Alzheimer's disease ...
Recent studies suggest that cellular senescence plays a role in Alzheimer’s Disease (AD) pathogenesi...
It is well known that the double-stranded RNA-dependent Protein Kinase (PKR) is not only activated i...
The phenotype and functional activity of circulating T and natural killer (NK) cells was investigat...
Brain aging is characterized by a progressive decline of the cognitive and memory functions. It is b...
Brain aging is characterized by a progressive decline of the cognitive and memory functions. It is b...