The pathophysiology of noninsulin-dependent diabetes mellitus (NIDDM) is characterized by insulin resistance and insulin deficiency. To search for genetic defects causing NIDDM, we have screened for mutations in the gene encoding insulin receptor substrate-1 (IRS-1), an intracellular protein that is phosphorylated by the insulin receptor and is thought to play an important role in mediating insulin action. The coding sequence of the IRS-1 gene (divided into 12 overlapping fragments) was amplified by polymerase chain reaction and screened for the presence of single stranded conformational polymorphisms. This led to the identification of 6 variants in the nucleotide sequence. There were 3 nonconservative amino acids substitutions: Gly819-->Ar...
Recent studies have identified several polymorphisms in the human insulin receptor substrate-1 (IRS-...
The gene encoding insulin receptor substrate-1 (IRS1) represents a strong biological candidate for a...
A population of 103 patients with non-insulin-dependent diabetes mellitus (NIDDM) was screened for m...
The pathophysiology of noninsulin-dependent diabetes mellitus (NIDDM) is characterized by insulin re...
The pathophysiology of noninsulin-dependent diabetes mellitus (NIDDM) is characterized by insulin re...
Several polymorphisms have been identified in the amino acid sequence of human insulin receptor subs...
Insulin receptor substrate-i (IRS-1) plays an important role in insulin-stimulated signaling mechani...
AimsTo define further the role of IRS-1 mutations in human syndromes of severe insulin resistance. M...
A glycine to arginine substitution (GGG↔AGG substitutions) in codon 972 (Gly 972 Arg) is the common...
The insulin receptor substrate-1 gene (IRS-1) gene has been considered a candidate for insulin resis...
Anas A Yousef,1 Eman G Behiry,1 Wafaa M Abd Allah,1 Ahmed M Hussien,2 Abdelmoneam A Abdelmoneam,2 Ma...
Insulin resistance is a common feature of non-insulin-depen-dent diabetes mellitus (NIDDM) and "...
Recent studies have identified several polymorphisms in the human insulin receptor substrate-1 (IRS-...
Insulin resistance is an early predictor of development of noninsulin-dependent diabetes mellitus (N...
Aims/hypothesis Activation of the insulin receptor substrate-1 (IRS1) is a key initial step in the i...
Recent studies have identified several polymorphisms in the human insulin receptor substrate-1 (IRS-...
The gene encoding insulin receptor substrate-1 (IRS1) represents a strong biological candidate for a...
A population of 103 patients with non-insulin-dependent diabetes mellitus (NIDDM) was screened for m...
The pathophysiology of noninsulin-dependent diabetes mellitus (NIDDM) is characterized by insulin re...
The pathophysiology of noninsulin-dependent diabetes mellitus (NIDDM) is characterized by insulin re...
Several polymorphisms have been identified in the amino acid sequence of human insulin receptor subs...
Insulin receptor substrate-i (IRS-1) plays an important role in insulin-stimulated signaling mechani...
AimsTo define further the role of IRS-1 mutations in human syndromes of severe insulin resistance. M...
A glycine to arginine substitution (GGG↔AGG substitutions) in codon 972 (Gly 972 Arg) is the common...
The insulin receptor substrate-1 gene (IRS-1) gene has been considered a candidate for insulin resis...
Anas A Yousef,1 Eman G Behiry,1 Wafaa M Abd Allah,1 Ahmed M Hussien,2 Abdelmoneam A Abdelmoneam,2 Ma...
Insulin resistance is a common feature of non-insulin-depen-dent diabetes mellitus (NIDDM) and "...
Recent studies have identified several polymorphisms in the human insulin receptor substrate-1 (IRS-...
Insulin resistance is an early predictor of development of noninsulin-dependent diabetes mellitus (N...
Aims/hypothesis Activation of the insulin receptor substrate-1 (IRS1) is a key initial step in the i...
Recent studies have identified several polymorphisms in the human insulin receptor substrate-1 (IRS-...
The gene encoding insulin receptor substrate-1 (IRS1) represents a strong biological candidate for a...
A population of 103 patients with non-insulin-dependent diabetes mellitus (NIDDM) was screened for m...