Changes in thyroid function across adolescence: a longitudinal study
- Campbell, Purdey J.
- Brown, Suzanne J.
- Kendrew, Phillip
- Lewer, Michelle
- Lim, Ee Mun
- Joseph, John
- Cross, Simone M.
- Wright, Margaret J.
- Martin, Nicholas G.
- Wilson, Scott G.
- Walsh, John P.
DOIAbstract
OBJECTIVE: There are no large, longitudinal studies of thyroid function across adolescence. The aims of this study were to examine longitudinal trends in thyrotropin (TSH), free triiodothyronine (fT3) and free thyroxine (fT4) and determine age-specific reference ranges. METHODS: Thyroid function was assessed in 3415 participants in the Brisbane Longitudinal Twin Study at ages 12, 14, and 16, using the Abbott ARCHITECT immunoassay. Longitudinal analyses were adjusted for body mass index and puberty. RESULTS: In girls, mean fT4 (± SE) increased between age 12 and 14 (by 0.30 ± 0.08 pmol/L; P
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