Catalytic enantioselective arylative cyclizations of alkynyl 1,3-diketones by 1,4-rhodium(i) migration
- Groves, Alistair
- Sun, Jinwei
- Parke, Hal R. I.
- Callingham, Michael
- Argent, Stephen P.
- Taylor, Laurence J.
- Lam, Hon Wai
Publication date
March 2020
DOI Publisher
Royal Society of Chemistry Language
EnglishAbstract
The enantioselective synthesis of densely functionalized polycarbocycles by the rhodium(I)-catalyzed reaction of arylboronic acids with 1,3-diketones is described. The key step in these desymmetrizing domino addition–cyclization reactions is an alkenyl-to-aryl 1,4-Rh(I) migration, which enables arylboronic acids to function effectively as 1,2-dimetalloarene surrogates
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