© 2016, American Society for Microbiology. All Rights Reserved. The highly pathogenic severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome coronavirus (MERS-CoV) cause significant morbidity and morality. There is currently no approved therapeutic for highly pathogenic coronaviruses, even as MERS-CoV is spreading throughout the Middle East. We previously screened a library of FDA-approved drugs for inhibitors of coronavirus replication in which we identified Abelson (Abl) kinase inhibitors, including the anticancer drug imatinib, as inhibitors of both SARS-CoV and MERS-CoV in vitro. Here we show that the anti-CoV activity of imatinib occurs at the early stages of infection, after internalization and e...
The global spread of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and the assoc...
International audienceOur therapeutic arsenal against viruses is very limited and the current pandem...
International audienceA novel coronavirus, named SARS-CoV-2, emerged in 2019 in China and rapidly sp...
SARS-CoV-2 has currently precipitated the COVID-19 global health crisis. We developed a medium-throu...
textabstractCoronaviruses can cause respiratory and enteric disease in a wide variety of human and a...
SARS-CoV-2 (COVID-19) is the causative organism for a pandemic disease with a high rate of infectivi...
Coronaviruses can cause respiratory and enteric disease in a wide variety of human and animal hosts....
Since the emergence of the severe acute respiratory syndrome coronavirus 2 (SARSCoV- 2) at the end o...
SARS-CoV-2 is a newly emerging infectious disease, which originated from Wuhan in the Hubei province...
The Middle East respiratory syndrome-coronavirus (MERS-CoV), first identified in Saudi Arabia, is an...
Following the emergence of SARS-CoV-2, the search for an effective and rapidly available treatment w...
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of coronavirus dis...
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of coronavirus dis...
A newly described coronavirus named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), wh...
The global spread of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and the assoc...
International audienceOur therapeutic arsenal against viruses is very limited and the current pandem...
International audienceA novel coronavirus, named SARS-CoV-2, emerged in 2019 in China and rapidly sp...
SARS-CoV-2 has currently precipitated the COVID-19 global health crisis. We developed a medium-throu...
textabstractCoronaviruses can cause respiratory and enteric disease in a wide variety of human and a...
SARS-CoV-2 (COVID-19) is the causative organism for a pandemic disease with a high rate of infectivi...
Coronaviruses can cause respiratory and enteric disease in a wide variety of human and animal hosts....
Since the emergence of the severe acute respiratory syndrome coronavirus 2 (SARSCoV- 2) at the end o...
SARS-CoV-2 is a newly emerging infectious disease, which originated from Wuhan in the Hubei province...
The Middle East respiratory syndrome-coronavirus (MERS-CoV), first identified in Saudi Arabia, is an...
Following the emergence of SARS-CoV-2, the search for an effective and rapidly available treatment w...
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of coronavirus dis...
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of coronavirus dis...
A newly described coronavirus named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), wh...
The global spread of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and the assoc...
International audienceOur therapeutic arsenal against viruses is very limited and the current pandem...
International audienceA novel coronavirus, named SARS-CoV-2, emerged in 2019 in China and rapidly sp...