CuZnSOD gene deletion targeted to skeletal muscle leads to loss of contractile force but does not cause muscle atrophy in adult mice

Skeletal muscle transcriptomics identifies common pathways in nerve crush injury and ageing

Staunton, CA
Owen, ED
Hemmings, K
Vasilaki, A
McArdle, A
Barrett-Jolley, R
Jackson, MJ

January 2022

Motor unit remodelling involving repeated denervation and re-innervation occurs throughout life. The...

Propeptide-mediated inhibition of myostatin increases muscle mass through inhibiting proteolytic pathways in aged mice

Matsakas, Antonios
Collins-Hooper, Henry
Dash, Philip R.
Flasskamp, Hannah
Foster, Keith
Macharia, Raymond
Patel, Ketan
Ray, Steve
Sandri, Marco
Sartori, Roberta
Visanuvimol, Korntip
Collins-Hooper, H.
Sartori, R.
Macharia, R.
Visanuvimol, K.
Foster, K.
Flasskamp, H.
Ray, S.
Dash, P. R.
Sandri, M.
Patel, K.

January 2014

Mammalian aging is accompanied by a progressive loss of skeletal muscle, a process called sarcopenia...

The cellular basis controlling the development of adult skeletal muscles

Elashry, Mohamed Ismail Elsayed

January 2011

A major strategy to alleviate myopathic symptoms through enhancing muscle growth and regeneration is...

Neuron‐specific expression of CuZnSOD prevents the loss of muscle mass and function that occurs in homozygous CuZnSOD‐knockout mice

Sakellariou, Giorgos K.
Davis, Carol S.
Shi, Yun
Ivannikov, Maxim V.
Zhang, Yiqiang
Vasilaki, Aphrodite
Macleod, Gregory T.
Richardson, Arlan
Van Remmen, Holly
Jackson, Malcolm J.
McArdle, Anne
Brooks, Susan V.

April 2014

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/154306/1/fsb2028004015.pd

Neuron specific reduction in CuZnSOD is not sufficient to initiate a full sarcopenia phenotype

Sataranatarajan, Kavithalakshmi
Qaisar, Rizwan
Davis, Carol
Sakellariou, Giorgos K.
Vasilaki, Aphrodite
Zhang, Yiqiang
Liu, Yuhong
Bhaskaran, Shylesh
McArdle, Anne
Jackson, Malcolm
Brooks, Susan V.
Richardson, Arlan
Van Remmen, Holly

August 2015

AbstractOur previous studies showed that adult (8 month) mice lacking CuZn-superoxide dismutase (CuZ...

Vasilaki, Aphrodite
Van Der Meulen, Jack H.
Larkin, Lisa M.
Harrison, Dawn C.
Pearson, Timothy
Van Remmen, Holly
Richardson, Arlan G.
Brooks, Susan V.
Jackson, Malcolm J.
Mcardle, Anne

December 2010

In muscle, aging is associated with a failure of adaptive responses to contractile activity, and thi...

Comparison of whole body SOD1 knockout with muscle specific SOD1 knockout mice reveals a role for nerve redox signaling in regulation of degenerative pathways in skeletal muscle.

Sakellariou, GK
McDonagh, B
Porter, H
Giakoumaki, II
Earl, KE
Nye, GA
Vasilaki, A
Brooks, SV
Richardson, A
Van Remmen, H
McArdle, A
Jackson, MJ

February 2018

Aims: Lack of Cu,Zn-superoxide dismutase (CuZnSOD) in homozygous knockout mice (Sod1−/−) leads to ac...

The Role of Cu, Zn Superoxide Dismutase (SOD1) in Muscle Stem Cell Function

Ergun, Utku

June 2021

Age-related loss of muscle mass and function often referred to as sarcopenia, dramatically affects t...

The lack of CuZnSOD leads to impaired neurotransmitter release, neuromuscular junction destabilization and reduced muscle strength in mice.

Yun Shi
Maxim V Ivannikov
Michael E Walsh
Yuhong Liu
Yiqiang Zhang
Carlos A Jaramillo
Gregory T Macleod
Holly Van Remmen

Elevated reactive oxygen species (ROS) production and ROS-dependent protein damage is a common obser...

Increased superoxide in vivo accelerates age‐associated muscle atrophy through mitochondrial dysfunction and neuromuscular junction degeneration

Jang, Youngmok C.
Lustgarten, Michael S.
Liu, Yuhong
Muller, Florian L.
Bhattacharya, Arunabh
Liang, Hanyu
Salmon, Adam B.
Brooks, Susan V.
Larkin, Lisa
Hayworth, Christopher R.
Richardson, Arlan
Van Remmen, Holly

May 2010

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/154668/1/fsb2fj09146308.pd

RESEARCH ARTICLE 0

August 2016

Maintenance of skeletal muscle mass is mainly achieved by a homeostatic balance between muscle regen...

Skeletal Muscle Is a Primary Target of SOD1G93A-Mediated Toxicity

Dobrowolny, Gabriella
Aucello, Michela
Rizzuto, Emanuele
Beccafico, Sara
Mammucari, Cristina
Bonconpagni, Simona
Belia, Silvia
Wannenes, Francesca
Nicoletti, Carmine
Del Prete, Zaccaria
Rosenthal, Nadia
Molinaro, Mario
Protasi, Feliciano
Fanò, Giorgio
Sandri, Marco
Musarò, Antonio

November 2008

SummaryThe antioxidant enzyme superoxide dismutase 1 (SOD1) is a critical player of the antioxidativ...

The effect of lengthening contractions on neuromuscular junction structure in adult and old mice

Vasilaki, Aphrodite
Pollock, Natalie
Giakoumaki, Ifigeneia
Goljanek-Whysall, Katarzyna
Sakellariou, Giorgos K.
Pearson, Timothy
Kayani, Anna
Jackson, Malcolm J.
McArdle, Anne

August 2016

Skeletal muscles of old mice demonstrate a profound inability to regenerate fully following damage. ...

Oxidative stress‐induced dysregulation of excitation–contraction coupling contributes to muscle weakness

Qaisar, Rizwan
Bhaskaran, Shylesh
Premkumar, Pavithra
Ranjit, Rojina
Natarajan, Kavithalakshmi Satara
Ahn, Bumsoo
Riddle, Kaitlyn
Claflin, Dennis R.
Richardson, Arlan
Brooks, Susan V.
Van Remmen, Holly

October 2018

BackgroundWe have previously shown that the deletion of the superoxide scavenger, CuZn superoxide di...

Image1.PDF

Jiaying Qiu (4959496)
Qingqing Fang (1413718)
Tongtong Xu (4959505)
Changyue Wu (4959502)
Lai Xu (1828831)
Lingbin Wang (4959499)
Xiaoming Yang (113295)
Shu Yu (645086)
Qi Zhang (28502)
Fei Ding (134577)
Hualin Sun (4959508)

March 2018

<p>Skeletal muscle atrophy occurs under various conditions, such as disuse, denervation, fasting, ag...

Skeletal muscle transcriptomics identifies common pathways in nerve crush injury and ageing

Staunton, CA
Owen, ED
Hemmings, K
Vasilaki, A
McArdle, A
Barrett-Jolley, R
Jackson, MJ

January 2022

Motor unit remodelling involving repeated denervation and re-innervation occurs throughout life. The...

Propeptide-mediated inhibition of myostatin increases muscle mass through inhibiting proteolytic pathways in aged mice

Matsakas, Antonios
Collins-Hooper, Henry
Dash, Philip R.
Flasskamp, Hannah
Foster, Keith
Macharia, Raymond
Patel, Ketan
Ray, Steve
Sandri, Marco
Sartori, Roberta
Visanuvimol, Korntip
Collins-Hooper, H.
Sartori, R.
Macharia, R.
Visanuvimol, K.
Foster, K.
Flasskamp, H.
Ray, S.
Dash, P. R.
Sandri, M.
Patel, K.

January 2014

Mammalian aging is accompanied by a progressive loss of skeletal muscle, a process called sarcopenia...

The cellular basis controlling the development of adult skeletal muscles

Elashry, Mohamed Ismail Elsayed

January 2011

A major strategy to alleviate myopathic symptoms through enhancing muscle growth and regeneration is...

Neuron‐specific expression of CuZnSOD prevents the loss of muscle mass and function that occurs in homozygous CuZnSOD‐knockout mice

Sakellariou, Giorgos K.
Davis, Carol S.
Shi, Yun
Ivannikov, Maxim V.
Zhang, Yiqiang
Vasilaki, Aphrodite
Macleod, Gregory T.
Richardson, Arlan
Van Remmen, Holly
Jackson, Malcolm J.
McArdle, Anne
Brooks, Susan V.

April 2014

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/154306/1/fsb2028004015.pd

Neuron specific reduction in CuZnSOD is not sufficient to initiate a full sarcopenia phenotype

Sataranatarajan, Kavithalakshmi
Qaisar, Rizwan
Davis, Carol
Sakellariou, Giorgos K.
Vasilaki, Aphrodite
Zhang, Yiqiang
Liu, Yuhong
Bhaskaran, Shylesh
McArdle, Anne
Jackson, Malcolm
Brooks, Susan V.
Richardson, Arlan
Van Remmen, Holly

August 2015

AbstractOur previous studies showed that adult (8 month) mice lacking CuZn-superoxide dismutase (CuZ...

Vasilaki, Aphrodite
Van Der Meulen, Jack H.
Larkin, Lisa M.
Harrison, Dawn C.
Pearson, Timothy
Van Remmen, Holly
Richardson, Arlan G.
Brooks, Susan V.
Jackson, Malcolm J.
Mcardle, Anne

December 2010

In muscle, aging is associated with a failure of adaptive responses to contractile activity, and thi...

Comparison of whole body SOD1 knockout with muscle specific SOD1 knockout mice reveals a role for nerve redox signaling in regulation of degenerative pathways in skeletal muscle.

Sakellariou, GK
McDonagh, B
Porter, H
Giakoumaki, II
Earl, KE
Nye, GA
Vasilaki, A
Brooks, SV
Richardson, A
Van Remmen, H
McArdle, A
Jackson, MJ

February 2018

Aims: Lack of Cu,Zn-superoxide dismutase (CuZnSOD) in homozygous knockout mice (Sod1−/−) leads to ac...

The Role of Cu, Zn Superoxide Dismutase (SOD1) in Muscle Stem Cell Function

Ergun, Utku

June 2021

Age-related loss of muscle mass and function often referred to as sarcopenia, dramatically affects t...

The lack of CuZnSOD leads to impaired neurotransmitter release, neuromuscular junction destabilization and reduced muscle strength in mice.

Yun Shi
Maxim V Ivannikov
Michael E Walsh
Yuhong Liu
Yiqiang Zhang
Carlos A Jaramillo
Gregory T Macleod
Holly Van Remmen

Elevated reactive oxygen species (ROS) production and ROS-dependent protein damage is a common obser...

Increased superoxide in vivo accelerates age‐associated muscle atrophy through mitochondrial dysfunction and neuromuscular junction degeneration

Jang, Youngmok C.
Lustgarten, Michael S.
Liu, Yuhong
Muller, Florian L.
Bhattacharya, Arunabh
Liang, Hanyu
Salmon, Adam B.
Brooks, Susan V.
Larkin, Lisa
Hayworth, Christopher R.
Richardson, Arlan
Van Remmen, Holly

May 2010

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/154668/1/fsb2fj09146308.pd

RESEARCH ARTICLE 0

August 2016

Maintenance of skeletal muscle mass is mainly achieved by a homeostatic balance between muscle regen...

Skeletal Muscle Is a Primary Target of SOD1G93A-Mediated Toxicity

Dobrowolny, Gabriella
Aucello, Michela
Rizzuto, Emanuele
Beccafico, Sara
Mammucari, Cristina
Bonconpagni, Simona
Belia, Silvia
Wannenes, Francesca
Nicoletti, Carmine
Del Prete, Zaccaria
Rosenthal, Nadia
Molinaro, Mario
Protasi, Feliciano
Fanò, Giorgio
Sandri, Marco
Musarò, Antonio

November 2008

SummaryThe antioxidant enzyme superoxide dismutase 1 (SOD1) is a critical player of the antioxidativ...

The effect of lengthening contractions on neuromuscular junction structure in adult and old mice

Vasilaki, Aphrodite
Pollock, Natalie
Giakoumaki, Ifigeneia
Goljanek-Whysall, Katarzyna
Sakellariou, Giorgos K.
Pearson, Timothy
Kayani, Anna
Jackson, Malcolm J.
McArdle, Anne

August 2016

Skeletal muscles of old mice demonstrate a profound inability to regenerate fully following damage. ...

Oxidative stress‐induced dysregulation of excitation–contraction coupling contributes to muscle weakness

Qaisar, Rizwan
Bhaskaran, Shylesh
Premkumar, Pavithra
Ranjit, Rojina
Natarajan, Kavithalakshmi Satara
Ahn, Bumsoo
Riddle, Kaitlyn
Claflin, Dennis R.
Richardson, Arlan
Brooks, Susan V.
Van Remmen, Holly

October 2018

BackgroundWe have previously shown that the deletion of the superoxide scavenger, CuZn superoxide di...

Image1.PDF

Jiaying Qiu (4959496)
Qingqing Fang (1413718)
Tongtong Xu (4959505)
Changyue Wu (4959502)
Lai Xu (1828831)
Lingbin Wang (4959499)
Xiaoming Yang (113295)
Shu Yu (645086)
Qi Zhang (28502)
Fei Ding (134577)
Hualin Sun (4959508)

March 2018

<p>Skeletal muscle atrophy occurs under various conditions, such as disuse, denervation, fasting, ag...

Skeletal muscle transcriptomics identifies common pathways in nerve crush injury and ageing

Staunton, CA
Owen, ED
Hemmings, K
Vasilaki, A
McArdle, A
Barrett-Jolley, R
Jackson, MJ

January 2022

Motor unit remodelling involving repeated denervation and re-innervation occurs throughout life. The...

Propeptide-mediated inhibition of myostatin increases muscle mass through inhibiting proteolytic pathways in aged mice

Matsakas, Antonios
Collins-Hooper, Henry
Dash, Philip R.
Flasskamp, Hannah
Foster, Keith
Macharia, Raymond
Patel, Ketan
Ray, Steve
Sandri, Marco
Sartori, Roberta
Visanuvimol, Korntip
Collins-Hooper, H.
Sartori, R.
Macharia, R.
Visanuvimol, K.
Foster, K.
Flasskamp, H.
Ray, S.
Dash, P. R.
Sandri, M.
Patel, K.

January 2014

Mammalian aging is accompanied by a progressive loss of skeletal muscle, a process called sarcopenia...

The cellular basis controlling the development of adult skeletal muscles

Elashry, Mohamed Ismail Elsayed

January 2011

A major strategy to alleviate myopathic symptoms through enhancing muscle growth and regeneration is...

CuZnSOD gene deletion targeted to skeletal muscle leads to loss of contractile force but does not cause muscle atrophy in adult mice

Abstract

Extracted data

CuZnSOD gene deletion targeted to skeletal muscle leads to loss of contractile force but does not cause muscle atrophy in adult mice

Abstract

Extracted data

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