An aldose reductase inhibitor reverses early diabetes‐induced changes in peripheral nerve function, metabolism, and antioxidative defense

A meta-analysis of trials on aldose reductase inhibitors in diabetic peripheral neuropathy. The Italian Study Group. The St. Vincent Declaration.

Nicolucci, A
Carinci, F
Cavaliere, D
Scorpiglione, N
Belfiglio, M
Labbrozzi, D
Mari, E
Benedetti, MM
Tognoni, G
Liberati, A

January 2020

Peripheral neuropathy is one of the most common and disabling long-term sequelae of diabetes mellitu...

Autonomic nervous function in experimentally diabetic rats: the effects of aldose reductase inhibition, dietary myo-inositol and thyroid hormone replacement

Asif M. Sardar (7166606)

January 1992

Neuropathy, a common complication of human diabetes, is not prevented by current antidiabetic therap...

Erythrocyte sorbitol level as a predictor of the efficacy of epalrestat treatment for diabetic peripheral polyneuropathy

Ando Hitoshi
Takamura Toshinari
Nagai Yukihiro
Kaneko Shuichi

November 2006

金沢大学医学部附属病院内科The relationship between the effect of aldose reductase inhibitors (ARIs) on the activa...

Aldose reductase-deficient mice are protected from delayed motor nerve conduction velocity, increased c-Jun NH2-terminal kinase activation, depletion of reduced glutathione, increased superoxide accumulation, and DNA damage

Arvindakshan, M
Ellery, CA
Oates, PJ
Ho, ECM
Yagihashi, S
Yuk, SC
Yip, JCW
Yamagishi, SI
Chung, SK
Lam, KSL
Chung, SSM

January 2006

The exaggerated flux through polyol pathway during diabetes is thought to be a major cause of lesion...

Effects of aldose reductase inhibitors on the progression of nerve fiber damage in diabetic neuropathy

Greene, Douglas A.

January 1992

Aldose reductase inhibitors improve nerve biochemistry, function, and structure in diabetic animals ...

Aldose reductase-deficient mice are protected from delayed motor nerve conduction velocity, increased c-jun NH2-terminal kinase activation, depletion of reduced glutathione, increased superoxide accumulation, and DNA damage

Ho, E. C. M.

The exaggerated flux through polyol pathway during diabetes is thought to be a major cause of lesion...

Evaluation of α1‐adrenoceptor antagonist on diabetes‐induced changes in peripheral nerve function, metabolism, and antioxidative defense

Obrosova, Irina G.
Van Huysen, Carol
Fathallah, Lamia
Cao, Xianghui
Stevens, Martin J.
Greene, Douglas A.

August 2000

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/154412/1/fsb2fj990803com.pd

Diabetes and the peripheral nerve

Obrosova, Irina G.

October 2009

AbstractDiabetes-induced damage to peripheral nerve culminates in development of peripheral diabetic...

Evaluation of a sorbitol dehydrogenase inhibitor on diabetic peripheral nerve metabolism: a prevention study

Obrosova, I. G.
Greene, Douglas A.
Fathallah, L.
Lang, H. J.

September 1999

Aims/hypothesis . Studies of the role of sorbitol dehydrogenase in nerve functional deficits induced...

Effect of hyperglycemia and the aldose reductase inhibitor tolrestat on sural nerve biochemistry and morphometry in advanced diabetic peripheral polyneuropathy

Sima, Anders A. F.
Greene, Douglas A.
Brown, Morton B.
Hohman, Thomas C.
Hicks, David B.
Graepel, G. Jay
Bochenek, Wieslaw J.
Beg, Mirza
Gonen, Boas

January 1993

Tolrestat is a well tolerated nonhydantoin aldose reductase inhibitor that has been reported to impr...

Aldose reductase-deficient mice with diabetes are protected from the motor nerve conduction velocity deficit and axonal atrophy

Chung, SK

January 2002

Recently, diabetes was recognized as an epidemic and considered as one of the major threats to huma...

Aldose Reductase Inhibition by AS-3201 in Sural Nerve From Patients With Diabetic

Sensorimotor Polyneuropathy
Vera Bril Md
Robert A. Buchanan

February 2015

OBJECTIVE — The primary purpose of this investigation was to determine whether AS-3201, a new aldose...

Preventive Effect of Long-term Aldose Reductase Inhibition (Ponalrestat) on Nerve Conduction and Sural Nerve Structure in the Spontaneously Diabetic Bio-Breeding Rat

Anders A. F. Sima
Ashok Prashar
Wei-xian Zhang
Subrata Chakrabarti
Douglas A. Greene

October 2016

To test the hypothesis that aldose reductase inhibition may prevent or delay the development of func...

Galactosemia produces ARI-preventable nodal changes similar to those of diabetic neuropathy

Kamijo, Mikiko
Basso, Michael
Varghese Cherian, P.
Hohman, Thomas C.
Sima, Anders A. F.

September 1994

The present study was designed to examine the development of structural changes, characteristic of d...

Pathogenesis of diabetic neuropathy--do hyperglycemia and aldose reductase inhibitors affect neuroactive steroid formation in the rat sciatic nerves?

A. Colciago
P. Negri-Cesi
F. Celotti

January 2002

The activation of the polyol pathway through aldose reductase (AR) might be involved in diabetic neu...

A meta-analysis of trials on aldose reductase inhibitors in diabetic peripheral neuropathy. The Italian Study Group. The St. Vincent Declaration.

Nicolucci, A
Carinci, F
Cavaliere, D
Scorpiglione, N
Belfiglio, M
Labbrozzi, D
Mari, E
Benedetti, MM
Tognoni, G
Liberati, A

January 2020

Peripheral neuropathy is one of the most common and disabling long-term sequelae of diabetes mellitu...

Autonomic nervous function in experimentally diabetic rats: the effects of aldose reductase inhibition, dietary myo-inositol and thyroid hormone replacement

Asif M. Sardar (7166606)

January 1992

Neuropathy, a common complication of human diabetes, is not prevented by current antidiabetic therap...

Erythrocyte sorbitol level as a predictor of the efficacy of epalrestat treatment for diabetic peripheral polyneuropathy

Ando Hitoshi
Takamura Toshinari
Nagai Yukihiro
Kaneko Shuichi

November 2006

金沢大学医学部附属病院内科The relationship between the effect of aldose reductase inhibitors (ARIs) on the activa...

Aldose reductase-deficient mice are protected from delayed motor nerve conduction velocity, increased c-Jun NH2-terminal kinase activation, depletion of reduced glutathione, increased superoxide accumulation, and DNA damage

Arvindakshan, M
Ellery, CA
Oates, PJ
Ho, ECM
Yagihashi, S
Yuk, SC
Yip, JCW
Yamagishi, SI
Chung, SK
Lam, KSL
Chung, SSM

January 2006

The exaggerated flux through polyol pathway during diabetes is thought to be a major cause of lesion...

Effects of aldose reductase inhibitors on the progression of nerve fiber damage in diabetic neuropathy

Greene, Douglas A.

January 1992

Aldose reductase inhibitors improve nerve biochemistry, function, and structure in diabetic animals ...

Aldose reductase-deficient mice are protected from delayed motor nerve conduction velocity, increased c-jun NH2-terminal kinase activation, depletion of reduced glutathione, increased superoxide accumulation, and DNA damage

Ho, E. C. M.

The exaggerated flux through polyol pathway during diabetes is thought to be a major cause of lesion...

Evaluation of α1‐adrenoceptor antagonist on diabetes‐induced changes in peripheral nerve function, metabolism, and antioxidative defense

Obrosova, Irina G.
Van Huysen, Carol
Fathallah, Lamia
Cao, Xianghui
Stevens, Martin J.
Greene, Douglas A.

August 2000

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/154412/1/fsb2fj990803com.pd

Diabetes and the peripheral nerve

Obrosova, Irina G.

October 2009

AbstractDiabetes-induced damage to peripheral nerve culminates in development of peripheral diabetic...

Evaluation of a sorbitol dehydrogenase inhibitor on diabetic peripheral nerve metabolism: a prevention study

Obrosova, I. G.
Greene, Douglas A.
Fathallah, L.
Lang, H. J.

September 1999

Aims/hypothesis . Studies of the role of sorbitol dehydrogenase in nerve functional deficits induced...

Effect of hyperglycemia and the aldose reductase inhibitor tolrestat on sural nerve biochemistry and morphometry in advanced diabetic peripheral polyneuropathy

Sima, Anders A. F.
Greene, Douglas A.
Brown, Morton B.
Hohman, Thomas C.
Hicks, David B.
Graepel, G. Jay
Bochenek, Wieslaw J.
Beg, Mirza
Gonen, Boas

January 1993

Tolrestat is a well tolerated nonhydantoin aldose reductase inhibitor that has been reported to impr...

Aldose reductase-deficient mice with diabetes are protected from the motor nerve conduction velocity deficit and axonal atrophy

Chung, SK

January 2002

Recently, diabetes was recognized as an epidemic and considered as one of the major threats to huma...

Aldose Reductase Inhibition by AS-3201 in Sural Nerve From Patients With Diabetic

Sensorimotor Polyneuropathy
Vera Bril Md
Robert A. Buchanan

February 2015

OBJECTIVE — The primary purpose of this investigation was to determine whether AS-3201, a new aldose...

Preventive Effect of Long-term Aldose Reductase Inhibition (Ponalrestat) on Nerve Conduction and Sural Nerve Structure in the Spontaneously Diabetic Bio-Breeding Rat

Anders A. F. Sima
Ashok Prashar
Wei-xian Zhang
Subrata Chakrabarti
Douglas A. Greene

October 2016

To test the hypothesis that aldose reductase inhibition may prevent or delay the development of func...

Galactosemia produces ARI-preventable nodal changes similar to those of diabetic neuropathy

Kamijo, Mikiko
Basso, Michael
Varghese Cherian, P.
Hohman, Thomas C.
Sima, Anders A. F.

September 1994

The present study was designed to examine the development of structural changes, characteristic of d...

Pathogenesis of diabetic neuropathy--do hyperglycemia and aldose reductase inhibitors affect neuroactive steroid formation in the rat sciatic nerves?

A. Colciago
P. Negri-Cesi
F. Celotti

January 2002

The activation of the polyol pathway through aldose reductase (AR) might be involved in diabetic neu...

A meta-analysis of trials on aldose reductase inhibitors in diabetic peripheral neuropathy. The Italian Study Group. The St. Vincent Declaration.

Nicolucci, A
Carinci, F
Cavaliere, D
Scorpiglione, N
Belfiglio, M
Labbrozzi, D
Mari, E
Benedetti, MM
Tognoni, G
Liberati, A

January 2020

Peripheral neuropathy is one of the most common and disabling long-term sequelae of diabetes mellitu...

Autonomic nervous function in experimentally diabetic rats: the effects of aldose reductase inhibition, dietary myo-inositol and thyroid hormone replacement

Asif M. Sardar (7166606)

January 1992

Neuropathy, a common complication of human diabetes, is not prevented by current antidiabetic therap...

Erythrocyte sorbitol level as a predictor of the efficacy of epalrestat treatment for diabetic peripheral polyneuropathy

Ando Hitoshi
Takamura Toshinari
Nagai Yukihiro
Kaneko Shuichi

November 2006

金沢大学医学部附属病院内科The relationship between the effect of aldose reductase inhibitors (ARIs) on the activa...

An aldose reductase inhibitor reverses early diabetes‐induced changes in peripheral nerve function, metabolism, and antioxidative defense

Abstract

Extracted data

An aldose reductase inhibitor reverses early diabetes‐induced changes in peripheral nerve function, metabolism, and antioxidative defense

Abstract

Extracted data

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