Neuron‐specific expression of CuZnSOD prevents the loss of muscle mass and function that occurs in homozygous CuZnSOD‐knockout mice

Conserved and species-specific molecular denominators in mammalian skeletal muscle aging

Mercken, Evi M
CAPRI, MIRIAM
Carboneau, Bethany A
CONTE, MARIA
Heidler, Juliana
SANTORO, AURELIA
Martin Montalvo, Alejandro
Gonzalez Freire, Marta
Khraiwesh, Husam
González Reyes, José A
Moaddel, Ruin
Zhang, Yongqing
Becker, Kevin G
Villalba, José M
Mattison, Julie A
Wittig, Ilka
FRANCESCHI, CLAUDIO
de Cabo, Rafael

January 2017

Aging is a complex phenomenon involving functional decline in multiple physiological systems. We und...

Local expression of SOD1G93A mutant protein triggers neuromuscular junction dismantlement

Dobrowolny, Gabriella
Martini, Martina
Romanello, Vanina
Boncompagni, Simona
Pietrangelo, Laura
Bouchè, Marina
Rudolf, Rüdiger
Protasi, Feliciano
Sandri, Marco
Musarò, Antonio

October 2017

The alteration of Reactive Oxygen Species (ROS) homeostasis plays a causal role in several chronic p...

nNOS/GSNOR interaction contributes to skeletal muscle differentiation and homeostasis

Montagna C.
Rizza S.
Cirotti C.
Maiani E.
Muscaritoli M.
Musaro A.
Carri M. T.
Ferraro E.
Cecconi F.
Filomeni G.

January 2019

Neuronal nitric oxide synthase (nNOS) plays a crucial role in the maintenance of correct skeletal mu...

CuZnSOD gene deletion targeted to skeletal muscle leads to loss of contractile force but does not cause muscle atrophy in adult mice

Zhang, Yiqiang
Davis, Carol
Sakellariou, George K.
Shi, Yun
Kayani, Anna C.
Pulliam, Daniel
Bhattacharya, Arunabh
Richardson, Arlan
Jackson, Malcolm J.
McArdle, Anne
Brooks, Susan V.
Van Remmen, Holly

September 2013

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/154374/1/fsb2027009015.pd

Neuron specific reduction in CuZnSOD is not sufficient to initiate a full sarcopenia phenotype

Sataranatarajan, Kavithalakshmi
Qaisar, Rizwan
Davis, Carol
Sakellariou, Giorgos K.
Vasilaki, Aphrodite
Zhang, Yiqiang
Liu, Yuhong
Bhaskaran, Shylesh
McArdle, Anne
Jackson, Malcolm
Brooks, Susan V.
Richardson, Arlan
Van Remmen, Holly

August 2015

AbstractOur previous studies showed that adult (8 month) mice lacking CuZn-superoxide dismutase (CuZ...

Vasilaki, Aphrodite
Van Der Meulen, Jack H.
Larkin, Lisa M.
Harrison, Dawn C.
Pearson, Timothy
Van Remmen, Holly
Richardson, Arlan G.
Brooks, Susan V.
Jackson, Malcolm J.
Mcardle, Anne

December 2010

In muscle, aging is associated with a failure of adaptive responses to contractile activity, and thi...

Comparison of whole body SOD1 knockout with muscle specific SOD1 knockout mice reveals a role for nerve redox signaling in regulation of degenerative pathways in skeletal muscle.

Sakellariou, GK
McDonagh, B
Porter, H
Giakoumaki, II
Earl, KE
Nye, GA
Vasilaki, A
Brooks, SV
Richardson, A
Van Remmen, H
McArdle, A
Jackson, MJ

February 2018

Aims: Lack of Cu,Zn-superoxide dismutase (CuZnSOD) in homozygous knockout mice (Sod1−/−) leads to ac...

The lack of CuZnSOD leads to impaired neurotransmitter release, neuromuscular junction destabilization and reduced muscle strength in mice.

Yun Shi
Maxim V Ivannikov
Michael E Walsh
Yuhong Liu
Yiqiang Zhang
Carlos A Jaramillo
Gregory T Macleod
Holly Van Remmen

Elevated reactive oxygen species (ROS) production and ROS-dependent protein damage is a common obser...

The Role of Cu, Zn Superoxide Dismutase (SOD1) in Muscle Stem Cell Function

Ergun, Utku

June 2021

Age-related loss of muscle mass and function often referred to as sarcopenia, dramatically affects t...

Redox homeostasis and age-related deficits in neuromuscular integrity and function

Sakellariou, GK
Lightfoot, AP
Earl, KE
Stofanko, M
McDonagh, B

Skeletal muscle is a major site of metabolic activity and is the most abundant tissue in the human b...

Increased superoxide in vivo accelerates age‐associated muscle atrophy through mitochondrial dysfunction and neuromuscular junction degeneration

Jang, Youngmok C.
Lustgarten, Michael S.
Liu, Yuhong
Muller, Florian L.
Bhattacharya, Arunabh
Liang, Hanyu
Salmon, Adam B.
Brooks, Susan V.
Larkin, Lisa
Hayworth, Christopher R.
Richardson, Arlan
Van Remmen, Holly

May 2010

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/154668/1/fsb2fj09146308.pd

CuZn-superoxide dismutase transgenic mice: no effect on longevity, locomotor activity and 3H-mazindol and 3H-spiperone binding over 19 months

Gallagher, I.
Jenner, P.
Glover, V.
Clow, A.
Gallagher, I.
Jenner, P.
Glover, V.
Clow, A.

August 2000

This study was designed to determine whether CuZn-superoxide dismutase (SOD) is neuroprotective agai...

Altered mitochondrial microenvironment at the spotlight of musculoskeletal aging and Alzheimer's disease

Giannos, Panagiotis
Prokopidis, Konstantinos
Raleigh, Stuart M
Kelaiditi, Eirini
Hill, Mathew

January 2022

Emerging evidence has linked Alzheimer's disease (AD) onset with musculoskeletal aging via a muscle-...

Deletion of Neuronal CuZnSOD Accelerates Age-Associated Muscle Mitochondria and Calcium Handling Dysfunction That Is Independent of Denervation and Precedes Sarcopenia

Yu Su
Dennis R. Claflin
Meixiang Huang
Carol S. Davis
Peter C. D. Macpherson
Arlan Richardson
Holly Van Remmen
Susan V. Brooks

October 2021

Skeletal muscle suffers atrophy and weakness with aging. Denervation, oxidative stress, and mitochon...

Skeletal muscle transcriptomics identifies common pathways in nerve crush injury and ageing

Staunton, CA
Owen, ED
Hemmings, K
Vasilaki, A
McArdle, A
Barrett-Jolley, R
Jackson, MJ

January 2022

Motor unit remodelling involving repeated denervation and re-innervation occurs throughout life. The...

Conserved and species-specific molecular denominators in mammalian skeletal muscle aging

Mercken, Evi M
CAPRI, MIRIAM
Carboneau, Bethany A
CONTE, MARIA
Heidler, Juliana
SANTORO, AURELIA
Martin Montalvo, Alejandro
Gonzalez Freire, Marta
Khraiwesh, Husam
González Reyes, José A
Moaddel, Ruin
Zhang, Yongqing
Becker, Kevin G
Villalba, José M
Mattison, Julie A
Wittig, Ilka
FRANCESCHI, CLAUDIO
de Cabo, Rafael

January 2017

Aging is a complex phenomenon involving functional decline in multiple physiological systems. We und...

Local expression of SOD1G93A mutant protein triggers neuromuscular junction dismantlement

Dobrowolny, Gabriella
Martini, Martina
Romanello, Vanina
Boncompagni, Simona
Pietrangelo, Laura
Bouchè, Marina
Rudolf, Rüdiger
Protasi, Feliciano
Sandri, Marco
Musarò, Antonio

October 2017

The alteration of Reactive Oxygen Species (ROS) homeostasis plays a causal role in several chronic p...

nNOS/GSNOR interaction contributes to skeletal muscle differentiation and homeostasis

Montagna C.
Rizza S.
Cirotti C.
Maiani E.
Muscaritoli M.
Musaro A.
Carri M. T.
Ferraro E.
Cecconi F.
Filomeni G.

January 2019

Neuronal nitric oxide synthase (nNOS) plays a crucial role in the maintenance of correct skeletal mu...

CuZnSOD gene deletion targeted to skeletal muscle leads to loss of contractile force but does not cause muscle atrophy in adult mice

Zhang, Yiqiang
Davis, Carol
Sakellariou, George K.
Shi, Yun
Kayani, Anna C.
Pulliam, Daniel
Bhattacharya, Arunabh
Richardson, Arlan
Jackson, Malcolm J.
McArdle, Anne
Brooks, Susan V.
Van Remmen, Holly

September 2013

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/154374/1/fsb2027009015.pd

Neuron specific reduction in CuZnSOD is not sufficient to initiate a full sarcopenia phenotype

Sataranatarajan, Kavithalakshmi
Qaisar, Rizwan
Davis, Carol
Sakellariou, Giorgos K.
Vasilaki, Aphrodite
Zhang, Yiqiang
Liu, Yuhong
Bhaskaran, Shylesh
McArdle, Anne
Jackson, Malcolm
Brooks, Susan V.
Richardson, Arlan
Van Remmen, Holly

August 2015

AbstractOur previous studies showed that adult (8 month) mice lacking CuZn-superoxide dismutase (CuZ...

Vasilaki, Aphrodite
Van Der Meulen, Jack H.
Larkin, Lisa M.
Harrison, Dawn C.
Pearson, Timothy
Van Remmen, Holly
Richardson, Arlan G.
Brooks, Susan V.
Jackson, Malcolm J.
Mcardle, Anne

December 2010

In muscle, aging is associated with a failure of adaptive responses to contractile activity, and thi...

Comparison of whole body SOD1 knockout with muscle specific SOD1 knockout mice reveals a role for nerve redox signaling in regulation of degenerative pathways in skeletal muscle.

Sakellariou, GK
McDonagh, B
Porter, H
Giakoumaki, II
Earl, KE
Nye, GA
Vasilaki, A
Brooks, SV
Richardson, A
Van Remmen, H
McArdle, A
Jackson, MJ

February 2018

Aims: Lack of Cu,Zn-superoxide dismutase (CuZnSOD) in homozygous knockout mice (Sod1−/−) leads to ac...

The lack of CuZnSOD leads to impaired neurotransmitter release, neuromuscular junction destabilization and reduced muscle strength in mice.

Yun Shi
Maxim V Ivannikov
Michael E Walsh
Yuhong Liu
Yiqiang Zhang
Carlos A Jaramillo
Gregory T Macleod
Holly Van Remmen

Elevated reactive oxygen species (ROS) production and ROS-dependent protein damage is a common obser...

The Role of Cu, Zn Superoxide Dismutase (SOD1) in Muscle Stem Cell Function

Ergun, Utku

June 2021

Age-related loss of muscle mass and function often referred to as sarcopenia, dramatically affects t...

Redox homeostasis and age-related deficits in neuromuscular integrity and function

Sakellariou, GK
Lightfoot, AP
Earl, KE
Stofanko, M
McDonagh, B

Skeletal muscle is a major site of metabolic activity and is the most abundant tissue in the human b...

Increased superoxide in vivo accelerates age‐associated muscle atrophy through mitochondrial dysfunction and neuromuscular junction degeneration

Jang, Youngmok C.
Lustgarten, Michael S.
Liu, Yuhong
Muller, Florian L.
Bhattacharya, Arunabh
Liang, Hanyu
Salmon, Adam B.
Brooks, Susan V.
Larkin, Lisa
Hayworth, Christopher R.
Richardson, Arlan
Van Remmen, Holly

May 2010

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/154668/1/fsb2fj09146308.pd

CuZn-superoxide dismutase transgenic mice: no effect on longevity, locomotor activity and 3H-mazindol and 3H-spiperone binding over 19 months

Gallagher, I.
Jenner, P.
Glover, V.
Clow, A.
Gallagher, I.
Jenner, P.
Glover, V.
Clow, A.

August 2000

This study was designed to determine whether CuZn-superoxide dismutase (SOD) is neuroprotective agai...

Altered mitochondrial microenvironment at the spotlight of musculoskeletal aging and Alzheimer's disease

Giannos, Panagiotis
Prokopidis, Konstantinos
Raleigh, Stuart M
Kelaiditi, Eirini
Hill, Mathew

January 2022

Emerging evidence has linked Alzheimer's disease (AD) onset with musculoskeletal aging via a muscle-...

Deletion of Neuronal CuZnSOD Accelerates Age-Associated Muscle Mitochondria and Calcium Handling Dysfunction That Is Independent of Denervation and Precedes Sarcopenia

Yu Su
Dennis R. Claflin
Meixiang Huang
Carol S. Davis
Peter C. D. Macpherson
Arlan Richardson
Holly Van Remmen
Susan V. Brooks

October 2021

Skeletal muscle suffers atrophy and weakness with aging. Denervation, oxidative stress, and mitochon...

Skeletal muscle transcriptomics identifies common pathways in nerve crush injury and ageing

Staunton, CA
Owen, ED
Hemmings, K
Vasilaki, A
McArdle, A
Barrett-Jolley, R
Jackson, MJ

January 2022

Motor unit remodelling involving repeated denervation and re-innervation occurs throughout life. The...

Conserved and species-specific molecular denominators in mammalian skeletal muscle aging

Mercken, Evi M
CAPRI, MIRIAM
Carboneau, Bethany A
CONTE, MARIA
Heidler, Juliana
SANTORO, AURELIA
Martin Montalvo, Alejandro
Gonzalez Freire, Marta
Khraiwesh, Husam
González Reyes, José A
Moaddel, Ruin
Zhang, Yongqing
Becker, Kevin G
Villalba, José M
Mattison, Julie A
Wittig, Ilka
FRANCESCHI, CLAUDIO
de Cabo, Rafael

January 2017

Aging is a complex phenomenon involving functional decline in multiple physiological systems. We und...

Local expression of SOD1G93A mutant protein triggers neuromuscular junction dismantlement

Dobrowolny, Gabriella
Martini, Martina
Romanello, Vanina
Boncompagni, Simona
Pietrangelo, Laura
Bouchè, Marina
Rudolf, Rüdiger
Protasi, Feliciano
Sandri, Marco
Musarò, Antonio

October 2017

The alteration of Reactive Oxygen Species (ROS) homeostasis plays a causal role in several chronic p...

nNOS/GSNOR interaction contributes to skeletal muscle differentiation and homeostasis

Montagna C.
Rizza S.
Cirotti C.
Maiani E.
Muscaritoli M.
Musaro A.
Carri M. T.
Ferraro E.
Cecconi F.
Filomeni G.

January 2019

Neuronal nitric oxide synthase (nNOS) plays a crucial role in the maintenance of correct skeletal mu...

Neuron‐specific expression of CuZnSOD prevents the loss of muscle mass and function that occurs in homozygous CuZnSOD‐knockout mice

Abstract

Extracted data

Neuron‐specific expression of CuZnSOD prevents the loss of muscle mass and function that occurs in homozygous CuZnSOD‐knockout mice

Abstract

Extracted data

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