A Staphylococcus aureus strain deleted for the c‐di‐AMP cyclase gene dacA is unable to survive in rich medium unless it acquires compensatory mutations. Previously identified mutations were in opuD, encoding the main glycine‐betaine transporter, and alsT, encoding a predicted amino acid transporter. Here, we show that inactivation of OpuD restores the cell size of a dacA mutant to near wild‐type (WT) size, while inactivation of AlsT does not. AlsT was identified as an efficient glutamine transporter, indicating that preventing glutamine uptake in rich medium rescues the growth of the S. aureus dacA mutant. In addition, GltS was identified as a glutamate transporter. By performing growth curves with WT, alsT and gltS mutant strains in define...
Staphylococcus aureus is a human pathogen capable of causing infections that range from mild skin an...
Staphylococcus aureus is an important human pathogen, with the ability to colonise and cause disease...
Nucleotide signaling networks are key to facilitate alterations in gene expression, protein function...
Cyclic di-adenosine monophosphate (c-di-AMP) is a signalling molecule that is important for the surv...
Cyclic di-adenosine monophosphate (c-di-AMP) is a recently discovered signaling molecule important f...
Staphylococcus aureus must rapidly adapt to a variety of carbon and nitrogen sources during invasion...
Staphylococcus aureus must rapidly adapt to a variety of carbon and nitrogen sources during invasion...
Staphylococcus aureus must rapidly adapt to a variety of carbon and nitrogen sources during invasion...
ABSTRACT Staphylococcus aureus must rapidly adapt to a variety of carbon and nitrogen sources during...
Staphylococcus aureus is an important opportunistic human pathogen that is highly resistant to osmo...
Staphylococcus aureus is metabolically diverse with the ability to rapidly adapt to a vast array of ...
Cyclic nucleotides that act as second messenger molecules play key roles in signaling pathways invol...
Branched-chain amino acids (BCAAs) act as effector molecules that signal a global transcriptional re...
The enormous spread of Staphylococcus aureus infections through biofilms is a major concern in hospi...
c-di-AMP is an important second messenger molecule that plays a pivotal role in regulating fundament...
Staphylococcus aureus is a human pathogen capable of causing infections that range from mild skin an...
Staphylococcus aureus is an important human pathogen, with the ability to colonise and cause disease...
Nucleotide signaling networks are key to facilitate alterations in gene expression, protein function...
Cyclic di-adenosine monophosphate (c-di-AMP) is a signalling molecule that is important for the surv...
Cyclic di-adenosine monophosphate (c-di-AMP) is a recently discovered signaling molecule important f...
Staphylococcus aureus must rapidly adapt to a variety of carbon and nitrogen sources during invasion...
Staphylococcus aureus must rapidly adapt to a variety of carbon and nitrogen sources during invasion...
Staphylococcus aureus must rapidly adapt to a variety of carbon and nitrogen sources during invasion...
ABSTRACT Staphylococcus aureus must rapidly adapt to a variety of carbon and nitrogen sources during...
Staphylococcus aureus is an important opportunistic human pathogen that is highly resistant to osmo...
Staphylococcus aureus is metabolically diverse with the ability to rapidly adapt to a vast array of ...
Cyclic nucleotides that act as second messenger molecules play key roles in signaling pathways invol...
Branched-chain amino acids (BCAAs) act as effector molecules that signal a global transcriptional re...
The enormous spread of Staphylococcus aureus infections through biofilms is a major concern in hospi...
c-di-AMP is an important second messenger molecule that plays a pivotal role in regulating fundament...
Staphylococcus aureus is a human pathogen capable of causing infections that range from mild skin an...
Staphylococcus aureus is an important human pathogen, with the ability to colonise and cause disease...
Nucleotide signaling networks are key to facilitate alterations in gene expression, protein function...