Some studies with quinazolines and related compounds

The thesis reports a study of new methods of modification of the medicinally important quinazoline system by the use of Reissert compounds. Previous attempts to employ this approach have utilized two phase conditions leading only to ring opened products. We have discovered that reaction of 4-phenylquinazoline with an acid chloride and trimethylsilyl cyanide as source of cyanide ion in a single phase system selectively gives a high yield route to the corresponding 1-acyl-2-cyano-1,2-dihydroquinazoline. [Continues.